Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 13/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.33 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749521 | 1.00 | HCAR2 (0.48) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL29222103 | 0.98 | HCAR2 (0.46) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL27869371 | 0.93 | HCAR2 (0.43) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL6150290 | 0.91 | HCAR2 (0.45) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL15260447 | 0.91 | HCAR2 (0.45) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL29148759 | 0.91 | HCAR2 (0.45) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL27558800 | 0.89 | HCAR2 (0.41) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL5681276 | 0.89 | HCAR2 (0.44) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL28896894 | 0.87 | ALDH1A1 (0.56) | HCAR2TSHRTP53EGLN1EGLN3 | |
| SCHEMBL6403988 | 0.87 | ALDH1A1 (0.56) | HCAR2TSHRTP53EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1032574-B1 | INDOLO 2,1-b|QUINAZOLE-6,12-DIONE ANTIMALARIAL COMPOUNDS AND METHODS OF TREATING MALARIA THEREWITH | US ARMY (US) | 2007-06-13 | — | — | EP | claimed |
| US-20030191138-A1 | Indolo[2,1-b] quinazole-6,12-dione antimalarial compounds and methods of treating malaria therewith | UNITED STATES ARMY | 2003-10-09 | — | — | US | claimed |
| US-6531487-B2 | Water solubility; bioavailability | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2003-03-11 | — | — | US | claimed |
| US-20010034350-A1 | Indolo[2,1-b] quinazole-6,12-dione antimalarial compounds and methods of treating malaria therewith | UNITED STATES ARMY | 2001-10-25 | — | — | US | claimed |
| US-6284772-B1 | OR PRODRUG THEREOF | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2001-09-04 | — | — | US | claimed |
| EP-1032574-A3 | INDOLO 2,1-b]QUINAZOLE-6,12-DIONE ANTIMALARIAL COMPOUNDS AND METHODS OF TREATING MALARIA THEREWITH | WRAIR (Walter Reed Army Institute of Research) (US) | 2000-12-20 | — | — | EP | claimed |
| EP-1032574-A2 | INDOLO 2,1-b]QUINAZOLE-6,12-DIONE ANTIMALARIAL COMPOUNDS AND METHODS OF TREATING MALARIA THEREWITH | WRAIR (Walter Reed Army Institute of Research) (US) | 2000-09-06 | — | — | EP | claimed |
| WO-2000018769-A2 | INDOLO[2,1-b]QUINAZOLE-6,12-DIONE ANTIMALARIAL COMPOUNDS AND METHODS OF TREATING MALARIA THEREWITH | WRAIR (WALTER REID ARMY INSTITUTE OF RESEARCH) (US) | 2000-04-06 | — | — | WO | claimed |
| US-4060623-A | 1,2,4-Triazole antimycotic compositions and use thereof | BAYER AKTIENGESELLSCHAFT (DT) | 1977-11-29 | — | — | US | claimed |
| US-4038406-A | 1,2,4-TRIAZOLE ANTIMYCOTIC COMPOSITIONS AND USE THEREOF | BAYER AKTIENGESELLSCHAFT (DT) | 1977-07-26 | — | — | US | claimed |
| US-4036966-A | 1,2,4-Triazole antimycotic compositions and use thereof | BAYER AKTIENGESELLSCHAFT (DT) | 1977-07-19 | — | — | US | claimed |
| US-4036967-A | 1,2,4-Triazole antimycotic compositions and use thereof | BAYER AKTIENGESELLSCHAFT (DT) | 1977-07-19 | — | — | US | claimed |
| CN-114790438-B | Method for improving yield and oxidation resistance of antrodia camphorata extracellular polysaccharide | 上海理工大学 | 2024-02-27 | — | — | CN | disclosed |
| CN-114790438-A | Method for improving yield and oxidation resistance of antrodia camphorata exopolysaccharide | 上海理工大学 | 2022-07-26 | — | — | CN | disclosed |
| US-11161830-B2 | 4-pyridone compound or salt thereof, and pharmaceutical composition and formulation including same | FUJIFILM CORPORATION (JP) | 2021-11-02 | — | — | US | disclosed |
| EP-3604301-B1 | 4-PYRIDONE COMPOUND OR SALT THEREOF, AND PHARMACEUTICAL COMPOSITION AND FORMULATION INCLUDING SAME | FUJIFILM CORP (JP) | 2021-09-22 | — | — | EP | disclosed |
| WO-1994012198-A1 | INJECTABLE TAXOL COMPOSITION | F.H. FAULDING & CO. LIMITED (AU) | 1994-06-09 | — | — | WO | disclosed |
| WO-1990005523-A2 | PHENANTHROLINEDICARBOXYLATE ESTERS, 4-AMINOQUINOLINE AND ISOQUINOLINE DERIVATIVES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE | THE UPJOHN COMPANY (US) | 1990-05-31 | — | — | WO | disclosed |
| US-4880815-A | GASTRIC JUICE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-11-14 | — | — | US | disclosed |
| US-4686273-A | Process for preparing modified poly(alkylene carbonate) polyahls | THE DOW CHEMICAL COMPANY (US) | 1987-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030191138-A1 | Indolo[2,1-b] quinazole-6,12-dione antimalarial compounds and methods of treating malaria therewith | HCCS, DAO, SCO2 | HCAR2 549/4885TSHR 3389/4885TP53 3547/4885 |
| US-11161830-B2 | 4-pyridone compound or salt thereof, and pharmaceutical composition and formulation including same | HAVCR2, HBS1L, PHKB | HCAR2 3148/4885TSHR 3112/4885TP53 666/4885 |
| US-20010034350-A1 | Indolo[2,1-b] quinazole-6,12-dione antimalarial compounds and methods of treating malaria therewith | HCCS, DAO, SCO2 | HCAR2 549/4885TSHR 3389/4885TP53 3547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.