Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.71 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.68 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.68 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | CDC42 | P60953 | 1/20 | 0.68 |
| ▸ | RAC1 | P63000 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3280876 | 1.00 | TDP1 (0.71) | TDP1L3MBTL1AKR1C3AKR1C2PTGS2 | |
| SCHEMBL31619540 | 1.00 | TDP1 (0.71) | TDP1L3MBTL1AKR1C3AKR1C2PTGS2 | |
| SCHEMBL221436 | 0.90 | TDP1 (0.71) | TDP1L3MBTL1AKR1C3AKR1C2PTGS2 | |
| SCHEMBL1246306 | 0.88 | TDP1 (0.68) | TDP1L3MBTL1AKR1C3AKR1C2PTGS2 | |
| SCHEMBL27746752 | 0.88 | TDP1 (0.68) | TDP1L3MBTL1AKR1C3AKR1C2PTGS2 | |
| SCHEMBL13063821 | 0.88 | TDP1 (0.71) | TDP1L3MBTL1AKR1C3AKR1C2PTGS2 | |
| SCHEMBL9289868 | 0.87 | PTGS2 (0.66) | TDP1L3MBTL1AKR1C3AKR1C2PTGS2 | |
| SCHEMBL9239307 | 0.87 | PTGS2 (0.66) | TDP1L3MBTL1AKR1C3AKR1C2PTGS2 | |
| SCHEMBL29156025 | 0.87 | TDP1 (0.69) | TDP1L3MBTL1AKR1C3AKR1C2PTGS2 | |
| SCHEMBL21340468 | 0.87 | TDP1 (0.69) | TDP1L3MBTL1AKR1C3AKR1C2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3975432-A | Process for preparing 2-(6-methoxy-2-naphthyl)propionic acid | SYNTEX CORPORATION (PM) | 1976-08-17 | — | — | US | claimed |
| US-8921591-B2 | Process for synthesizing phenylacetic acid by carbonylation of toluene | LANZHOU INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES (CN) | 2014-12-30 | — | — | US | disclosed |
| US-20130303798-A1 | PROCESS FOR SYNTHESIZING PHENYLACETIC ACID BY CARBONYLATION OF TOLUENE | LANZHOU INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES (CN) | 2013-11-14 | — | — | US | disclosed |
| CN-102388014-A | Synthesis method of chiral alpha-aryl propionic acid derivative | DSM IP ASSETS BV | 2012-03-21 | — | — | CN | disclosed |
| US-20120029226-A1 | METHOD FOR THE SYNTHESIS OF CHIRAL ALPHA-ARYL PROPIONIC ACID DERIVATIVES | DSM IP ASSETS B.V. (NL) | 2012-02-02 | — | — | US | disclosed |
| EP-2393771-A1 | Method for the synthesis of chiral alpha-aryl propionic acid derivatives | DSM IP Assets B.V. (NL) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089343-A1 | METHOD FOR THE SYNTHESIS OF CHIRAL ALPHA-ARYL PROPIONIC ACID DERIVATIVES | DSM IP ASSETS B.V. (NL) | 2010-08-12 | — | — | WO | disclosed |
| EP-0973714-A2 | PRODUCTION OF RACEMIC 2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACID OR PRECURSORS THEREOF | ALBEMARLE CORPORATION (US) | 2000-01-26 | — | — | EP | disclosed |
| US-5912164-A | TREATING ENANTIOMERS WITH ENZYME TO ENRICH SOLUTION FOR CARBOXYLIC ACID OR ALCOHOL; EFFICIENT PRODUCTION OF ANTIINFLAMMATORY AGENTS USING BIOCATALYST | LABORATORIOS MENARINI S.A. (ES) | 1999-06-15 | — | — | US | disclosed |
| EP-0426656-B1 | Process for the preparation of 2-arylpropionic acids | GIST BROCADES NV (NL) | 1999-03-03 | — | — | EP | disclosed |
| US-4605758-A | Preparation of α-arylalkanoic acids | SYNTEX PHARMACEUTICALS INTERNATIONAL LTD. (BM) | 1986-08-12 | — | — | US | disclosed |
| US-4577025-A | Method of preparing α-aromatic propionic acids and intermediates thereof | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1986-03-18 | — | — | US | disclosed |
| EP-0074008-B1 | PROCESS FOR PRODUCING ALPHA-ARYLALKANOIC ACID ESTERS | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1984-10-10 | — | — | EP | disclosed |
| US-4433160-A | Process for producing α-arylalkanoic acid ester | TAISHO PHARMACEUTICAL COMPANY, LTD. (JP) | 1984-02-21 | — | — | US | disclosed |
| US-4417070-A | PREFERENTIAL CRYSTALLIZATION | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1983-11-22 | — | — | US | disclosed |
| EP-0081993-A2 | Optically active alpha-substituted aryl ketones, their preparation and their use in preparing alpha-arylalkanoic acids | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1983-06-22 | — | — | EP | disclosed |
| EP-0074008-A2 | Process for producing alpha-arylalkanoic acid esters | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1983-03-16 | — | — | EP | disclosed |
| US-4048330-A | Compositions containing 2-(6'-substituted-2'-naphthyl)acetic acid esters used for treating inflammation, pain or pyrexia | SYNTEX CORPORATION (US) | 1977-09-13 | — | — | US | disclosed |
| US-4009197-A | 2-(6-Substituted-2'-naphthyl) acetic acid derivatives and the salts and esters thereof | SYNTEX CORPORATION (PM) | 1977-02-22 | — | — | US | disclosed |
| US-3975432-A | Process for preparing 2-(6-methoxy-2-naphthyl)propionic acid | SYNTEX CORPORATION (PM) | 1976-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303798-A1 | PROCESS FOR SYNTHESIZING PHENYLACETIC ACID BY CARBONYLATION OF TOLUENE | DDT, HPD, PAH | TDP1 1153/4885L3MBTL1 3633/4885AKR1C3 440/4885 |
| US-20120029226-A1 | METHOD FOR THE SYNTHESIS OF CHIRAL ALPHA-ARYL PROPIONIC ACID DERIVATIVES | GRIA1, GRIA3, GRIA2 | TDP1 4606/4885L3MBTL1 4261/4885AKR1C3 233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.