Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5067727 | 0.87 | NPC1 (0.42) | HTTHSD17B10ALDH1A1KDM4EKMT2A | |
| SCHEMBL2187511 | 0.86 | NPC1 (0.44) | LMNAHTTHSD17B10ALDH1A1KDM4E | |
| SCHEMBL226315 | 0.75 | KMT2A (0.55) | LMNAHTTPOLBALDH1A1SMN1; SMN2 | |
| Morpholine Salicylate SCHEMBL24540 | 0.74 | RAB9A (0.59) | LMNAHSD17B10ALDH1A1KDM4ESMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL11880905 | 0.73 | KMT2A (0.54) | LMNAHTTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL27640541 | 0.73 | PKM (0.59) | LMNAHTTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL10594875 | 0.72 | MAPT (0.49) | LMNAHSD17B10ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL27579023 | 0.70 | RAB9A (0.47) | LMNAHTTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL27551530 | 0.70 | KMT2A (0.66) | HTTALDH1A1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL28781903 | 0.68 | ALDH1A1 (0.59) | LMNAHTTPOLBALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051386-A1 | Tricyclic Pyrazole Derivatives as Cannabinoid Receptor Modulators | CADILA HEALTHCARE LIMITED (IN) | 2008-02-28 | — | — | US | claimed |
| EP-1781668-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS | CADILA HEALTHCARE LTD. (IN) | 2007-05-09 | — | — | EP | claimed |
| WO-2006025069-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2006-03-09 | — | — | WO | claimed |
| US-20080051386-A1 | Tricyclic Pyrazole Derivatives as Cannabinoid Receptor Modulators | CADILA HEALTHCARE LIMITED (IN) | 2008-02-28 | — | — | US | disclosed |
| EP-1781668-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS | CADILA HEALTHCARE LTD. (IN) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006025069-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2006-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051386-A1 | Tricyclic Pyrazole Derivatives as Cannabinoid Receptor Modulators | CNR2, CNR1, GPR55 | LMNA 4462/4885HTT 4059/4885HSD17B10 2747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.