Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.47 |
| ▸ | NPC1 | O15118 | 7/20 | 0.47 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | METAP2 | P50579 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL147654 | 0.83 | KDM4E (0.60) | FGFR1FLT1KDM4ENPC1RAB9A | |
| SCHEMBL30860691 | 0.83 | KDM4E (0.60) | FGFR1FLT1KDM4ENPC1RAB9A | |
| SCHEMBL5819055 | 0.70 | FGFR1 (0.53) | FGFR1FLT1KDM4ENPC1RAB9A | |
| SCHEMBL717809 | 0.70 | NPC1 (0.67) | FGFR1FLT1KDM4ENPC1RAB9A | |
| SCHEMBL30277951 | 0.70 | NPC1 (0.67) | FGFR1FLT1KDM4ENPC1RAB9A | |
| SCHEMBL6161364 | 0.68 | F10 (0.54) | CHEK1 | |
| SCHEMBL4115108 | 0.67 | FGFR1 (0.58) | FGFR1FLT1KDM4ENPC1RAB9A | |
| SCHEMBL311148 | 0.66 | FGFR1 (1.00) | FGFR1FLT1KDM4ENPC1RAB9A | |
| Benzene SCHEMBL29179821 | 0.66 | RAB9A (0.64) | FGFR1FLT1KDM4ENPC1RAB9A | |
| SCHEMBL29714859 | 0.66 | FGFR1 (1.00) | FGFR1FLT1KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080146540-A1 | Methods of diagnosis and treatment for asthma, allergic rhinitis and other respiratory diseases based on haplotype association | DECODE GENETICS EHF. (IS) | 2008-06-19 | — | — | US | disclosed |
| EP-1848436-A2 | METHODS OF DIAGNOSIS AND TREATMENT FOR ASTHMA, ALLERGIC RHINITIS AND OTHER RESPIRATORY DISEASES BASED ON HAPLOTYPE ASSOCIATION | Decode Genetics EHF. (IS) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006081555-A2 | METHODS OF DIAGNOSIS AND TREATMENT FOR ASTHMA, ALLERGIC RHINITIS AND OTHER RESPIRATORY DISEASES BASED ON HAPLOTYPE ASSOCIATION | DECODE GENETICS EHF. (IS) | 2006-08-03 | — | — | WO | disclosed |
| EP-1646372-A2 | METHODS OF DIAGNOSIS AND TREATMENT FOR ASTHMA BASED ON HAPLOTYPE ASSOCIATION | Decode Genetics EHF. (IS) | 2006-04-19 | — | — | EP | disclosed |
| US-20060014165-A1 | Methods of diagnosis and treatment for asthma and other respiratory diseases based on haplotype association | DECODE GENETICS EHF. (IS) | 2006-01-19 | — | — | US | disclosed |
| WO-2005007144-A2 | METHOD OF DIAGNOSIS AND TREATMENT FOR ASTHMA BASED ON HAPLOTYPE ASSOCIATION | DECODE GENETICS EHF (IS) | 2005-01-27 | — | — | WO | disclosed |
| US-6306849-B1 | FUSED HETEROCYCLIC COMPOUNDS WITH ETHER, AMIDES, ESTER AND AMINES | CEPHALON, INC. | 2001-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146540-A1 | Methods of diagnosis and treatment for asthma, allergic rhinitis and other respiratory diseases based on haplotype association | MAP3K9, MAP4K5, MAP3K19 | FGFR1 2308/4885FLT1 3370/4885KDM4E 2444/4885 |
| US-20060014165-A1 | Methods of diagnosis and treatment for asthma and other respiratory diseases based on haplotype association | MAP3K9, MAP3K19, MAP4K5 | FGFR1 2983/4885FLT1 3965/4885KDM4E 2931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.