Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.41 |
| ▸ | TTR | P02766 | 2/20 | 0.41 |
| ▸ | PTPRC | P08575 | 2/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5879567 | 0.75 | TDP2 (0.61) | TDP2ALDH1A1SRD5A2TTRPTPRC | |
| SCHEMBL18010815 | 0.72 | TDP2 (1.00) | TDP2SRD5A2 | |
| SCHEMBL20894239 | 0.72 | PARP10 (0.58) | TDP2ALDH1A1SRD5A2SRD5A1KDM4E | |
| SCHEMBL29631237 | 0.72 | PARP10 (0.58) | TDP2ALDH1A1SRD5A2SRD5A1KDM4E | |
| SCHEMBL7400636 | 0.69 | TDP2 (0.50) | TDP2ALDH1A1SRD5A2TTRPTPRC | |
| SCHEMBL17327530 | 0.68 | TDP2 (0.62) | TDP2ALDH1A1SRD5A2TTRPTPRC | |
| SCHEMBL16130136 | 0.68 | SRD5A2 (0.68) | TDP2ALDH1A1SRD5A2TTRPTPRC | |
| SCHEMBL7050731 | 0.68 | TTR (0.58) | TDP2ALDH1A1SRD5A2TTRPTPRC | |
| SCHEMBL28440350 | 0.68 | SRD5A2 (0.67) | TDP2ALDH1A1SRD5A2TTRPTPRC | |
| Isophthalic Acid SCHEMBL28032858 | 0.68 | PARP10 (0.53) | TDP2ALDH1A1SRD5A2SRD5A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2131656-A2 | PHTHALAZINE DERIVATIVES | Forest Laboratories Holdings Limited (BM) | 2009-12-16 | — | — | EP | claimed |
| WO-2008061108-A2 | PHTHALAZINE DERIVATIVES | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-05-22 | — | — | WO | claimed |
| EP-2131656-A2 | PHTHALAZINE DERIVATIVES | Forest Laboratories Holdings Limited (BM) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008061108-A2 | PHTHALAZINE DERIVATIVES | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-05-22 | — | — | WO | disclosed |