Sugi Predict

Sugi Predict / Compounds / Succinic Acid

Succinic Acid

Succinic Acid

SCHEMBL506729

C1=Cc2ccccc2CC=N1.O=C(O)CCC(=O)O

nearest known ligand 0.37

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4

The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NOTUM Q6P988 1/20 0.37
▸ NR4A2 P43354 1/20 0.37
▸ KDM4E B2RXH2 2/20 0.35
▸ L3MBTL1 Q9Y468 2/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ POLB P06746 1/20 0.35
▸ MAPT P10636 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35
▸ KEAP1 Q14145 1/20 0.34
▸ ALDH1A1 P00352 3/20 0.34
▸ CYP2C19 P33261 2/20 0.34
▸ GAA P10253 1/20 0.34
▸ MAOA P21397 1/20 0.34
▸ MAOB P27338 1/20 0.34
▸ TSHR P16473 2/20 0.34
▸ ALOX15 P16050 1/20 0.34
▸ SIRT1 Q96EB6 1/20 0.34
▸ FFAR1 O14842 2/20 0.33
▸ SMN1; SMN2 Q16637 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL208144 0.85 CA1 (0.40) TRPA1CA1CA2
Trifluoroacetic Acid SCHEMBL5455015 0.83 CES1 (0.33) MAOAMAOBCA1CA2
Water SCHEMBL16428036 0.83 CA1 (0.43) TRPA1CA1CA2
Hydrochloric Acid SCHEMBL506406 0.83 PARP1 (0.39) TRPA1CA1CA2
SCHEMBL27693919 0.83 CA1 (0.39) TRPA1CA1CA2
Water SCHEMBL16428037 0.83 CA1 (0.43) TRPA1CA1CA2
Hydrochloric Acid SCHEMBL28783882 0.81 CA1 (0.42) CA1CA2
Succinic Acid SCHEMBL28209032 0.73 LMNA (0.35) NR4A2LMNA
SCHEMBL29860173 0.67 CA1 (0.38) CYP2C19CA1CA2CYP2D6
Indene SCHEMBL6273661 0.67 CYP2D6 (0.45) KDM4EL3MBTL1MAPTCYP2C19MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8580780-B2 6 substituted 2, 3,4,5 tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonist ELI LILLY AND COMPANY (US) 2013-11-12 — — US disclosed
US-20120028961-A1 6 Substituted 2, 3,4,5 Tetrahydro-1H-Benzo[d]Azepines as 5-HT2c Receptor Agonist ELI LILLY AND COMPANY (US) 2012-02-02 — — US disclosed
US-8022062-B2 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists ELI LILLY AND COMPANY (US) 2011-09-20 — — US disclosed
US-20090099155-A1 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS ARRAY BIOPHARMA, INC. 2009-04-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090099155-A1 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS HTR2C, HTR5A, HTR4 NOTUM 3840/4885NR4A2 68/4885KDM4E 1208/4885
US-20120028961-A1 6 Substituted 2, 3,4,5 Tetrahydro-1H-Benzo[d]Azepines as 5-HT2c Receptor Agonist HTR2C, HTR4, HTR1A NOTUM 3904/4885NR4A2 205/4885KDM4E 623/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.