Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MARS1 | P56192 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4420284 | 0.81 | GRN (0.40) | CA1CA2PKMKMORAB9A | |
| SCHEMBL14843883 | 0.81 | KMO (0.40) | SMN1; SMN2KMOFNTAFNTBPGGT1B | |
| SCHEMBL2800230 | 0.80 | SLC7A5 (0.46) | PKMKMO | |
| SCHEMBL4403267 | 0.78 | MDM2 (0.44) | SMN1; SMN2KMORAB9ANPC1MEN1 | |
| SCHEMBL6897797 | 0.77 | NPC1 (0.38) | CA1CA2PKMLMNASMN1; SMN2 | |
| SCHEMBL5067808 | 0.73 | HDAC8 (0.41) | LMNATSHRRAB9ANPC1ALDH1A1 | |
| SCHEMBL2333132 | 0.71 | KMT2A (0.57) | LMNASMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL7168442 | 0.71 | HSD11B1 (0.42) | CA1CA2SMN1; SMN2KMORAB9A | |
| SCHEMBL6228047 | 0.69 | TSHR (0.42) | PKMLMNASMN1; SMN2TSHRFNTA | |
| Racemethionine SCHEMBL28833032 | 0.69 | KIF11 (0.48) | PKMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917020-A1 | MONOMETHYLVALINE COMPOUNDS HAVING PHENYLALANINE SIDE-CHAIN MODIFICATIONS AT THE C-TERMINUS | Seattle Genetics, Inc. (US) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007008603-A1 | MONOMETHYLVALINE COMPOUNDS HAVING PHENYLALANINE SIDE-CHAIN MODIFICATIONS AT THE C-TERMINUS | SEATTLE GENETICS, INC. (US) | 2007-01-18 | — | — | WO | disclosed |