Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4420284 | 0.83 | GRN (0.40) | NPC1RAB9APKMALDH1A1POLB | |
| SCHEMBL8507553 | 0.82 | CES2 (0.49) | ALDH1A1CES2CES1MAPTALOX15 | |
| SCHEMBL14843883 | 0.80 | KMO (0.40) | NPC1RAB9AALDH1A1POLBCES2 | |
| SCHEMBL2800230 | 0.78 | SLC7A5 (0.46) | PKMKMO | |
| SCHEMBL5067796 | 0.77 | CA1 (0.38) | NPC1RAB9APKMALDH1A1SMN1; SMN2 | |
| SCHEMBL7432353 | 0.77 | PGR (0.48) | NPC1RAB9AALDH1A1POLBCES2 | |
| SCHEMBL19318480 | 0.77 | PGR (0.48) | NPC1RAB9AALDH1A1POLBCES2 | |
| SCHEMBL8228098 | 0.77 | PGR (0.48) | NPC1RAB9AALDH1A1POLBCES2 | |
| SCHEMBL4403267 | 0.76 | MDM2 (0.44) | NPC1RAB9ASMN1; SMN2HDAC1MEN1 | |
| Hydrochloric Acid SCHEMBL10728681 | 0.75 | MAPT (0.49) | NPC1RAB9AALDH1A1POLBCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11629171-B2 | Beta-hairpin peptidomimetics | SPEXIS AG (CH) | 2023-04-18 | — | — | US | disclosed |
| US-20210284693-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | SPEXIS AG (CH) | 2021-09-16 | — | — | US | disclosed |
| US-10829520-B2 | Beta-hairpin peptidomimetics | POLYPHOR AG (CH) | 2020-11-10 | — | — | US | disclosed |
| CN-111770932-A | Beta-hairpin peptidomimetics | 波利弗尔股份公司 | 2020-10-13 | — | — | CN | disclosed |
| EP-3707153-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | Polyphor Ag (CH) | 2020-09-16 | — | — | EP | disclosed |
| US-20180072775-A1 | Beta-Hairpin Peptidomimetics | POLYPHOR AG (CH) | 2018-03-15 | — | — | US | disclosed |
| EP-3274361-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | Polyphor Ag (CH) | 2018-01-31 | — | — | EP | disclosed |
| CN-107636007-A | Beta hairpin peptide mimics | 波利弗尔股份公司 | 2018-01-26 | — | — | CN | disclosed |
| WO-2016150576-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | POLYPHOR AG (CH) | 2016-09-29 | — | — | WO | disclosed |
| EP-1155435-A4 | ELECTRO-PNEUMATIC DISTRIBUTOR FOR MULTIPLEXED $g(m)-TAS DEVICES | UNIV NORTHEASTERN (US) | 2004-08-11 | — | — | EP | disclosed |
| EP-1155435-A1 | ELECTRO-PNEUMATIC DISTRIBUTOR FOR MULTIPLEXED $g(m)-TAS DEVICES | NORTHEASTERN UNIVERSITY (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000041214-A1 | ELECTRO-PNEUMATIC DISTRIBUTOR FOR MULTIPLEXED ν-TAS DEVICES | NORTHEASTERN UNIVERSITY (US) | 2000-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11629171-B2 | Beta-hairpin peptidomimetics | POLL, POLQ, HBZ | NPC1 4602/4885RAB9A 3521/4885PKM 262/4885 |
| US-20180072775-A1 | Beta-Hairpin Peptidomimetics | POLQ, POLL, POLM | NPC1 4582/4885RAB9A 3511/4885PKM 328/4885 |
| US-20210284693-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | POLL, POLQ, POLM | NPC1 4663/4885RAB9A 4045/4885PKM 196/4885 |
| US-10829520-B2 | Beta-hairpin peptidomimetics | POLQ, POLL, POLM | NPC1 4582/4885RAB9A 3511/4885PKM 328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.