Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21331550 | 0.77 | ALDH1A1 (0.43) | SMN1; SMN2NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL7264636 | 0.74 | DRD2 (0.35) | SMN1; SMN2KDM4EHSD17B10ALDH1A1MAPT | |
| SCHEMBL10535351 | 0.73 | TSHR (0.45) | SMN1; SMN2NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL29636414 | 0.70 | GRM5 (0.49) | KDM4EHSD17B10ALDH1A1MAPTHPGD | |
| SCHEMBL852452 | 0.70 | GRM5 (0.49) | KDM4EHSD17B10ALDH1A1MAPTHPGD | |
| SCHEMBL17614917 | 0.69 | KDM4E (0.35) | KDM4EHSD17B10ALDH1A1MAPTHPGD | |
| SCHEMBL27595208 | 0.68 | HPGD (0.41) | SMN1; SMN2NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL30655640 | 0.68 | GPR3 (0.39) | SMN1; SMN2NPC1RAB9AKDM4EHSD17B10 | |
| SCHEMBL17792035 | 0.67 | ELANE (0.43) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL21331572 | 0.66 | ABL1 (0.49) | SMN1; SMN2NPC1RAB9AHDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1319231-A4 | PROGRAMMABLE MOLECULAR DEVICE | UNIV WM MARSH RICE (US) | 2008-11-19 | — | — | EP | disclosed |
| EP-1319231-A1 | PROGRAMMABLE MOLECULAR DEVICE | Wm. MARSH RICE UNIVERSITY (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002009117-A1 | PROGRAMMABLE MOLECULAR DEVICE | WM. MARSH RICE UNIVERSITY (US) | 2002-01-31 | — | — | WO | disclosed |