Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28686570 | 0.84 | TRPA1 (0.42) | SMN1; SMN2HTR2AHRH1POLBKDM4E | |
| SCHEMBL10899009 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2AOC3HTR2AHRH1POLB | |
| SCHEMBL26136303 | 0.80 | TAAR1 (0.44) | AOC3HTR2AHRH1POLBKDM4E | |
| SCHEMBL6717543 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2AOC3HTR2AHRH1POLB | |
| SCHEMBL3472313 | 0.78 | AOC3 (0.43) | SMN1; SMN2AOC3HRH1LMNAMMP13 | |
| SCHEMBL5700304 | 0.78 | SMN1; SMN2 (0.42) | SMN1; SMN2AOC3POLBLMNAMMP13 | |
| SCHEMBL3141262 | 0.78 | SRC (0.50) | SMN1; SMN2AOC3HTR2AHRH1POLB | |
| SCHEMBL16690471 | 0.76 | MMP13 (0.55) | SMN1; SMN2AOC3ALDH1A1LMNAMAPT | |
| SCHEMBL11758456 | 0.75 | SMN1; SMN2 (0.40) | SMN1; SMN2AOC3HTR2AHRH1POLB | |
| SCHEMBL8661391 | 0.75 | ALDH1A1 (0.43) | SMN1; SMN2POLBKDM4EGMNNALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893222-A2 | ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS | Merck & Co., Inc. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006138163-A2 | ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS | MERCK & CO., INC. (US) | 2006-12-28 | — | — | WO | disclosed |