Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.43 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.41 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8658264 | 0.83 | CYP2C19 (0.42) | ALDH1A1CYP2C19GABBR2GABBR1PDE4A | |
| SCHEMBL23174395 | 0.81 | CYP2C19 (0.46) | ALDH1A1CYP2C19GABBR2GABBR1PDE4A | |
| SCHEMBL5998430 | 0.80 | CYP2C19 (0.47) | ALDH1A1CYP2C19GABBR2GABBR1NPSR1 | |
| SCHEMBL26136303 | 0.80 | TAAR1 (0.44) | ALDH1A1GABBR2GABBR1NPSR1SLC6A3 | |
| SCHEMBL28686570 | 0.77 | TRPA1 (0.42) | ALDH1A1CYP2C19PDE4APDE4BPDE4C | |
| SCHEMBL19183147 | 0.75 | SRC (0.47) | ALDH1A1CYP2C19NPSR1CYP2D6SLC6A3 | |
| SCHEMBL5070388 | 0.75 | SMN1; SMN2 (0.44) | ALDH1A1CYP2C19NPSR1CYP1A2CYP2D6 | |
| SCHEMBL16348724 | 0.73 | ALDH1A1 (0.56) | ALDH1A1CYP2C19NPSR1CYP1A2CYP2D6 | |
| SCHEMBL16403447 | 0.71 | NPSR1 (0.40) | ALDH1A1NPSR1CYP1A2CYP2D6PKM | |
| SCHEMBL5674838 | 0.71 | ATM (0.49) | ALDH1A1CYP2C19NPSR1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625516-B1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | claimed |
| EP-0625516-A1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LIMITED (GB) | 1994-11-23 | — | — | EP | claimed |
| EP-0625516-B1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| EP-0625516-A1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LIMITED (GB) | 1994-11-23 | — | — | EP | disclosed |