Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 9/20 | 0.48 |
| ▸ | MME | P08473 | 8/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5135601 | 1.00 | ECE1 (0.48) | ECE1MMEHDAC8ACEMEN1 | |
| SCHEMBL5069554 | 0.90 | ECE1 (0.48) | ECE1MMEHDAC8MEN1KMT2A | |
| SCHEMBL5071371 | 0.90 | ECE1 (0.55) | ECE1MME | |
| SCHEMBL5041973 | 0.89 | ALDH1A1 (0.49) | ECE1MMEHDAC8MMP8MMP14 | |
| SCHEMBL5134614 | 0.89 | ECE1 (0.51) | ECE1MMEHDAC8MMP8MMP14 | |
| SCHEMBL5034289 | 0.83 | ECE1 (0.53) | ECE1MMEMMP8MMP14CTSS | |
| SCHEMBL5137875 | 0.83 | ACE2 (0.48) | ECE1MMEHDAC8KMT2ACTSS | |
| SCHEMBL5070497 | 0.80 | ECE1 (0.49) | ECE1MMEHDAC8MMP8MMP14 | |
| SCHEMBL5073912 | 0.79 | HDAC8 (0.43) | MMEHDAC8ACEKMT2ACTSS | |
| SCHEMBL6929264 | 0.79 | ACE2 (0.62) | ECE1MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685142-B1 | PHOSPHINIC ACID DERIVATIVES, BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | disclosed |