Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 17/20 | 0.55 |
| ▸ | MME | P08473 | 15/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5134614 | 0.94 | ECE1 (0.51) | ECE1MMEACE2 | |
| SCHEMBL5070528 | 0.90 | ECE1 (0.48) | ECE1MME | |
| SCHEMBL5135601 | 0.90 | ECE1 (0.48) | ECE1MME | |
| SCHEMBL5041973 | 0.89 | ALDH1A1 (0.49) | ECE1MME | |
| SCHEMBL5069554 | 0.89 | ECE1 (0.48) | ECE1MME | |
| SCHEMBL5070497 | 0.85 | ECE1 (0.49) | ECE1MMEACE2 | |
| SCHEMBL6929264 | 0.85 | ACE2 (0.62) | ECE1MMEACE2 | |
| SCHEMBL7621126 | 0.84 | ECE1 (0.74) | ECE1MME | |
| SCHEMBL6927137 | 0.81 | ECE1 (0.72) | ECE1MME | |
| SCHEMBL5070534 | 0.79 | ECE1 (0.48) | ECE1MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685142-B1 | PHOSPHINIC ACID DERIVATIVES, BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | disclosed |