Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | POLQ | O75417 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5068890 | 0.80 | POLQ (0.48) | LMNATP53MAPTPOLQKMT2A | |
| SCHEMBL8263373 | 0.73 | ALDH1A1 (0.58) | LMNAPOLQKMT2ANPC1ROCK2 | |
| SCHEMBL7451732 | 0.73 | NPC1 (0.36) | LMNANPC1PKMALDH1A1POLB | |
| SCHEMBL11438169 | 0.73 | ROCK2 (0.47) | LMNATP53MAPTPOLQKMT2A | |
| SCHEMBL1331254 | 0.73 | — | — | |
| SCHEMBL20899861 | 0.72 | POLQ (0.46) | LMNATP53MAPTPOLQKMT2A | |
| SCHEMBL98627 | 0.71 | KMT2A (0.54) | POLQKMT2AALDH1A1POLBMEN1 | |
| SCHEMBL1760632 | 0.70 | KMT2A (0.58) | LMNAPOLQKMT2ANPC1ALDH1A1 | |
| SCHEMBL5601309 | 0.69 | KMT2A (0.56) | POLQKMT2AALDH1A1POLBMEN1 | |
| SCHEMBL9887 | 0.69 | KMT2A (0.56) | TP53POLQKMT2ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896394-A1 | SUBSTITUTED ENAMINONES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | The Regents of the University of California (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006138510-A1 | SUBSTITUTED ENAMINONES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-12-28 | — | — | WO | disclosed |