Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 12/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL135240 | 0.86 | TACR1 (0.40) | TACR1ALDH1A1MEN1KMT2A | |
| SCHEMBL5067467 | 0.83 | TACR1 (0.40) | TACR1 | |
| SCHEMBL129898 | 0.82 | CETP (0.43) | ALDH1A1 | |
| SCHEMBL132751 | 0.78 | ALDH1A1 (0.40) | TACR1ALDH1A1MEN1KMT2A | |
| SCHEMBL5067463 | 0.77 | TACR1 (0.36) | TACR1 | |
| SCHEMBL5067462 | 0.76 | TACR1 (0.37) | TACR1 | |
| SCHEMBL1587634 | 0.68 | SLC6A4 (0.40) | TACR1 | |
| SCHEMBL130203 | 0.67 | CETP (0.45) | — | |
| SCHEMBL132026 | 0.67 | CETP (0.45) | MEN1KMT2A | |
| SCHEMBL27694957 | 0.67 | AKR1B10 (0.47) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979331-A1 | TRISUBSTITUTED AMINE COMPOUNDS AS INHIBITORS OF -CHOLESTERYL ESTER TRANSFER PROTEIN CETP | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007088996-A1 | TRISUBSTITUTED AMINE COMPOUNDS AS INHIBITORS OF -CHOLESTERYL ESTER TRANSFER PROTEIN CETP | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-08-09 | — | — | WO | disclosed |