Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 17/20 | 0.56 |
| ▸ | THRB | P10828 | 17/20 | 0.56 |
| ▸ | PCNA | P12004 | 2/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3127267 | 0.89 | THRA (0.44) | THRATHRBPCNA | |
| SCHEMBL5859480 | 0.81 | THRA (0.64) | THRATHRBPCNAESR1NR3C1 | |
| SCHEMBL5073534 | 0.78 | THRA (0.60) | THRATHRBPCNAESR1NR3C1 | |
| SCHEMBL3912492 | 0.77 | SMN1; SMN2 (0.48) | THRATHRBPCNA | |
| SCHEMBL3127272 | 0.74 | HTT (0.46) | THRATHRBPOLB | |
| SCHEMBL28801013 | 0.74 | THRA (0.56) | THRATHRBPCNAESR1NR3C1 | |
| SCHEMBL3137350 | 0.74 | HPGD (0.52) | THRATHRB | |
| SCHEMBL7069928 | 0.71 | THRA (1.00) | THRATHRB | |
| SCHEMBL5381964 | 0.71 | THRA (0.60) | THRATHRBPCNAFFAR1 | |
| SCHEMBL3131477 | 0.70 | THRB (0.48) | THRATHRBPCNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899309-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003419-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2007-01-11 | — | — | WO | disclosed |