Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 15/20 | 0.64 |
| ▸ | THRB | P10828 | 15/20 | 0.64 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.54 |
| ▸ | PCNA | P12004 | 2/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5073534 | 0.86 | THRA (0.60) | THRATHRBFFAR1PCNAESR1 | |
| SCHEMBL5859452 | 0.85 | THRB (0.62) | THRATHRB | |
| SCHEMBL14553370 | 0.84 | FFAR1 (0.55) | THRATHRBFFAR1PCNAPOLB | |
| SCHEMBL14485308 | 0.83 | PCNA (0.77) | THRATHRBFFAR1PCNAPGR | |
| SCHEMBL5363057 | 0.81 | THRB (0.76) | THRATHRB | |
| SCHEMBL28801013 | 0.81 | THRA (0.56) | THRATHRBFFAR1PCNAESR1 | |
| SCHEMBL5074381 | 0.81 | THRA (0.56) | THRATHRBFFAR1PCNAESR1 | |
| SCHEMBL4528982 | 0.80 | THRA (0.49) | THRATHRB | |
| SCHEMBL12312510 | 0.79 | THRB (0.50) | THRATHRB | |
| SCHEMBL5282025 | 0.78 | THRB (0.52) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144909-B2 | Phenoxy substituted benzocondensed heteroaryl derivatives as thyroid receptor ligands | KARO BIO AB (SE) | 2006-12-05 | — | — | US | disclosed |
| US-20040116387-A1 | Phenoxy substituted benzocondensed heteroaryl derivatives as thyroid receptor ligands | KARO BIO AB (SE) | 2004-06-17 | — | — | US | disclosed |