SCHEMBL5074802

SCHEMBL5074802

O=C(c1ccc(S)cc1)N1CCNCC1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.68
HPGD P15428 2/20 0.61
MKNK1 Q9BUB5 1/20 0.54
MKNK2 Q9HBH9 1/20 0.54
ALDH1A1 P00352 1/20 0.52
GABRD O14764 1/20 0.50
GABRA1 P14867 1/20 0.50
GABRB1 P18505 1/20 0.50
GABRA5 P31644 1/20 0.50
GABRA3 P34903 1/20 0.50
GABRA2 P47869 1/20 0.50
GABRB2 P47870 1/20 0.50
GABRA4 P48169 1/20 0.50
L3MBTL3 Q96JM7 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
RXFP1 Q9HBX9 1/20 0.47
EPHX2 P34913 1/20 0.47
RIPK1 Q13546 1/20 0.46
TDO2 P48775 1/20 0.46
CCNC P24863 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21650771 0.92 SIGMAR1 (0.58) SIGMAR1HPGDMKNK1MKNK2ALDH1A1
SCHEMBL8358137 0.90 SIGMAR1 (0.81) SIGMAR1HPGDMKNK1MKNK2ALDH1A1
SCHEMBL8260488 0.85 SIGMAR1 (0.72) SIGMAR1HPGDMKNK1MKNK2ALDH1A1
SCHEMBL3583338 0.85 HPGD (0.73) SIGMAR1HPGDMKNK1MKNK2ALDH1A1
SCHEMBL23140495 0.83 SIGMAR1 (0.76) SIGMAR1HPGDMKNK1MKNK2ALDH1A1
SCHEMBL4505138 0.83 SIGMAR1 (0.70) SIGMAR1HPGDMKNK1MKNK2ALDH1A1
SCHEMBL13600346 0.81 HPGD (0.70) SIGMAR1HPGDMKNK1MKNK2ALDH1A1
SCHEMBL304221 0.81 SIGMAR1 (0.68) SIGMAR1HPGDMKNK1MKNK2ALDH1A1
SCHEMBL1256167 0.81 SIGMAR1 (0.68) SIGMAR1HPGDALDH1A1RXFP1CCNC
SCHEMBL1409459 0.81 SIGMAR1 (0.68) SIGMAR1HPGDMKNK1MKNK2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3241554-B1 QUINOLINE-8-SULFONAMIDE DERIVATIVES HAVING AN ANTICANCER ACTIVITY AGIOS PHARMACEUTICALS INC (US) 2020-01-29 EP disclosed
EP-1965798-A2 USEFUL COMBINATIONS OF MONOBACTAM ANTIBIOTICS WITH BETA-LACTAMASE INHIBITORS Basilea Pharmaceutica AG (CH) 2008-09-10 EP disclosed
WO-2007065288-A2 USEFUL COMBINATIONS OF MONOBACTAM ANTIBIOTICS WITH BETA-LACTAMASE INHIBITORS BASILEA PHARMACEUTICA AG (CH) 2007-06-14 WO disclosed