SCHEMBL5074997

SCHEMBL5074997

COc1ccc(C(=O)c2cc(Oc3cc(C(C)(C)C)cc(C(C)(C)C)c3)cc(Oc3cc(C(C)(C)C)cc(C(C)(C)C)c3)c2)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.51
TUBB4A P04350 1/20 0.51
TUBB P07437 1/20 0.51
TUBA3C P0DPH7 1/20 0.51
TUBA1B P68363 1/20 0.51
TUBA4A P68366 1/20 0.51
TUBB4B P68371 1/20 0.51
TUBB3 Q13509 1/20 0.51
TUBB2A Q13885 1/20 0.51
TUBB8 Q3ZCM7 1/20 0.51
TUBA3E Q6PEY2 1/20 0.51
TUBA1A Q71U36 1/20 0.51
TUBA1C Q9BQE3 1/20 0.51
TUBB6 Q9BUF5 1/20 0.51
TUBB2B Q9BVA1 1/20 0.51
TUBB1 Q9H4B7 1/20 0.51
ALDH1A1 P00352 2/20 0.50
LMNA P02545 2/20 0.50
MAPK1 P28482 2/20 0.50
ALOX15 P16050 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5075015 0.89 MAPT (0.58) MAPTTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL5075836 0.87 ELANE (0.50) MAPTALDH1A1LMNAMAPK1GAA
SCHEMBL18627186 0.86 MAPT (0.58) MAPTTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL25471518 0.83 MAPT (0.68) MAPTTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL12799179 0.81 TUBB4A (0.60) MAPTTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL19830567 0.81 MAPT (0.74) MAPTTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL395599 0.81 MAPT (0.74) MAPTTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL3545138 0.81 TUBB4A (0.68) MAPTTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL5073345 0.80 SRD5A2 (0.62) MAPTTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL5079225 0.79 ELANE (0.53) MAPTALDH1A1LMNAMAPK1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1359176-B1 Polycarbonates, polyestercarbonates and polyesters having specific branched endgroups BAYER MATERIALSCIENCE AG (DE) 2008-08-27 EP disclosed
US-6825312-B2 POLYCARBONATESTER COPOLYMER MOLDING MATERIALS BAYER AKTIENGESELLSCHAFT (DE) 2004-11-30 US disclosed
US-20040030090-A1 Polycarbonates, polyester carbonates and polyesters with special branched terminal groups BAYER AKTIENGESELLSCHAFT (DE) 2004-02-12 US disclosed
EP-1359176-A2 Polycarbonates, polyestercarbonates and polyesters having specific branched endgroups Bayer Aktiengesellschaft (DE) 2003-11-05 EP disclosed