SCHEMBL3545138

SCHEMBL3545138

COc1ccc(C(=O)c2cc(OC)cc(OC)c2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A P04350 1/20 0.68
TUBB P07437 1/20 0.68
TUBA3C P0DPH7 1/20 0.68
TUBA1B P68363 1/20 0.68
TUBA4A P68366 1/20 0.68
TUBB4B P68371 1/20 0.68
TUBB3 Q13509 1/20 0.68
TUBB2A Q13885 1/20 0.68
TUBB8 Q3ZCM7 1/20 0.68
TUBA3E Q6PEY2 1/20 0.68
TUBA1A Q71U36 1/20 0.68
TUBA1C Q9BQE3 1/20 0.68
TUBB6 Q9BUF5 1/20 0.68
TUBB2B Q9BVA1 1/20 0.68
TUBB1 Q9H4B7 1/20 0.68
MEN1 O00255 3/20 0.66
KMT2A Q03164 3/20 0.66
RAB9A P51151 3/20 0.66
MAPT P10636 3/20 0.66
NPSR1 Q6W5P4 2/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12362759 0.91 TUBB4A (0.72) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL1817008 0.89 ALDH1A1 (0.58) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL9418310 0.89 RXFP1 (0.79) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL51509 0.89 RXFP1 (0.79) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL12799179 0.89 TUBB4A (0.60) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL15431499 0.89 TUBB4A (0.60) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL2464374 0.86 HTT (0.59) MEN1KMT2ARAB9ALMNAMAPK1
Ethyne SCHEMBL8195983 0.85 RXFP1 (0.73) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL5073345 0.84 SRD5A2 (0.62) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL9999619 0.84 LMNA (0.61) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116660543-A Diagnostic and prognostic markers for nonalcoholic fatty liver disease and uses thereof 中国人民解放军陆军军医大学第一附属医院 2023-08-29 CN claimed
US-12534548-B2 Bleaching agent, preparation and use of the same with polymerizable compositions for optical materials MITSUI CHEMICALS, INC. (JP) 2026-01-27 US disclosed
US-12448470-B2 Polymerizable composition for optical material, molded product, optical material, and plastic lens and method for manufacturing same MITSUI CHEMICALS, INC. (JP) 2025-10-21 US disclosed
US-20250002724-A1 METHOD FOR MANUFACTURING AN OPTICAL MATERIAL AND COMPOSITION USED IN THIS METHOD MITSUI CHEMICALS, INC. (JP) 2025-01-02 US disclosed
EP-3722840-B1 POLYMERIZABLE COMPOSITION FOR OPTICAL MATERIAL, AND MOLDED ARTICLE MITSUI CHEMICALS INC (JP) 2024-12-04 EP disclosed
CN-114599689-B Bleaching agent, preparation thereof and use thereof with polymerizable compositions for optical materials 三井化学株式会社 2024-05-31 CN disclosed
EP-4327139-A1 METHOD FOR MANUFACTURING AN OPTICAL MATERIAL AND COMPOSITION USED IN THIS METHOD Mitsui Chemicals, Inc. (JP) 2024-02-28 EP disclosed
CN-116940867-A Method for manufacturing optical material and composition used in the method 三井化学株式会社 2023-10-24 CN disclosed
US-20220403065-A1 BLEACHING AGENT, PREPARATION AND USE OF THE SAME WITH POLYMERIZABLE COMPOSITIONS FOR OPTICAL MATERIALS MITSUI CHEMICALS, INC. (JP) 2022-12-22 US disclosed
WO-2022224928-A1 METHOD FOR MANUFACTURING AN OPTICAL MATERIAL AND COMPOSITION USED IN THIS METHOD MITSUI CHEMICALS, INC. (JP) 2022-10-27 WO disclosed
CN-101053558-A Diphenylethylene compounds and uses thereof CELGENE CORP (US) 2007-10-17 CN disclosed
EP-1799634-A2 DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF CELGENE CORPORATION (US) 2007-06-27 EP disclosed
EP-1603864-A4 DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF CELGENE CORP (US) 2007-04-11 EP disclosed
WO-2006026747-A2 DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF CELGENE CORPORATION (US) 2006-03-09 WO disclosed
EP-1603864-A2 DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF CELGENE CORPORATION (US) 2005-12-14 EP disclosed
US-20050240062-A1 Structural modification of resveratrol: Sodium resverastatin phosphate NATIONAL INSTITUTES OF HEALTH 2005-10-27 US disclosed
US-20050107339-A1 Diphenylethylene compounds and uses thereof CELGENE CORPORATION 2005-05-19 US disclosed
US-20050014727-A1 Diphenylethylene compounds and uses thereof CELGENE CORPORATION 2005-01-20 US disclosed
WO-2004078144-A2 DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF CELGENE CORPORATION (US) 2004-09-16 WO disclosed
WO-2003086414-A1 STRUCTURAL MODIFICATION OF RESVERATROL: SODIUM RESVERASTATIN PHOSPHATE ARIZONA BOARD OF REGENTS (US) 2003-10-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050107339-A1 Diphenylethylene compounds and uses thereof VHL, TNF, PTGES TUBB4A 2850/4885TUBB 3365/4885TUBA3C 2433/4885
US-20050240062-A1 Structural modification of resveratrol: Sodium resverastatin phosphate PI4KB, HDAC4, PIK3CA TUBB4A 436/4885TUBB 1612/4885TUBA3C 3019/4885
US-12534548-B2 Bleaching agent, preparation and use of the same with polymerizable compositions for optical materials HBB, HBZ, CASP12 TUBB4A 456/4885TUBB 455/4885TUBA3C 1468/4885
US-20050014727-A1 Diphenylethylene compounds and uses thereof VHL, TNF, PTGES TUBB4A 2850/4885TUBB 3365/4885TUBA3C 2433/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.