Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.82 |
| ▸ | MAPT | P10636 | 5/20 | 0.82 |
| ▸ | MEN1 | O00255 | 5/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.82 |
| ▸ | TTR | P02766 | 4/20 | 0.82 |
| ▸ | HPGD | P15428 | 4/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.82 |
| ▸ | RECQL | P46063 | 3/20 | 0.82 |
| ▸ | TSHR | P16473 | 3/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.82 |
| ▸ | LMNA | P02545 | 3/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.82 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.82 |
| ▸ | POLB | P06746 | 2/20 | 0.82 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.82 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.82 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.82 |
| ▸ | CASP7 | P55210 | 2/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rhein SCHEMBL25253 | 0.90 | ALDH1A1 (1.00) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| Rhein SCHEMBL29404324 | 0.90 | ALDH1A1 (1.00) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| Rhein SCHEMBL8012677 | 0.89 | ALDH1A1 (0.97) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| Rhein SCHEMBL23632984 | 0.89 | ALDH1A1 (0.97) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| Rhein SCHEMBL1357918 | 0.89 | ALDH1A1 (0.97) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| Rhein SCHEMBL23632879 | 0.89 | ALDH1A1 (0.97) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| Rhein SCHEMBL23633120 | 0.89 | ALDH1A1 (0.97) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| Rhein SCHEMBL23632868 | 0.89 | ALDH1A1 (0.97) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| Rhein SCHEMBL526035 | 0.89 | ALDH1A1 (0.97) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| Rhein SCHEMBL1356821 | 0.89 | ALDH1A1 (0.97) | ALDH1A1MAPTMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1913940-B1 | RHEIN CONJUGATES, PREPARATION METHOD THEREOF AND THEIR USES IN PRODUCING MEDICINES FOR TREATING DIABETIC NEPHROSIS, INTESTINAL ADHESION AND OSTEOARTHRITIS | CONG XIAODONG (CN) | 2018-11-21 | — | — | EP | disclosed |
| US-9181172-B2 | Rhein conjugates, preparation method thereof and their uses in producing medicines for treating diabetic nephrosis, intestinal adhesion and osteoarthritis | CONG XIAODONG (CN) | 2015-11-10 | — | — | US | disclosed |
| US-20080207758-A1 | Reaction product of rhein with bases or amino acids; antidiabetic agents; gastrointestinal disorders; antiarthritic agents | CONG XIAODONG | 2008-08-28 | — | — | US | disclosed |
| EP-1913940-A1 | RHEIN CONJUGATES, PREPARATION METHOD THEREOF AND THEIR USES IN PRODUCING MEDICINES FOR TREATING DIABETIC NEPHROSIS, INTESTINAL ADHESION AND OSTEOARTHRITIS | Jiangsu Lianchuang Pharmaceutical Technology Co. (CN) | 2008-04-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207758-A1 | Reaction product of rhein with bases or amino acids; antidiabetic agents; gastrointestinal disorders; antiarthritic agents | ARGLU1, RO60, CROCC | ALDH1A1 3432/4885MAPT 3631/4885MEN1 837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.