Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Rhein. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR known ✓ | P02766 | 4/20 | 0.97 |
| ▸ | HSP90AA1 known ✓ | P07900 | 2/20 | 0.97 |
| ▸ | HSP90AB1 known ✓ | P08238 | 2/20 | 0.97 |
| ▸ | BCHE known ✓ | P06276 | 1/20 | 0.97 |
| ▸ | MAOA known ✓ | P21397 | 3/20 | 0.62 |
| ▸ | MAOB known ✓ | P27338 | 2/20 | 0.62 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.53 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.53 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.53 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.53 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.53 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.53 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.53 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.53 |
| ▸ | AVPR1A known ✓ | P37288 | 1/20 | 0.53 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.97 |
| ▸ | MAPT | P10636 | 5/20 | 0.97 |
| ▸ | MEN1 | O00255 | 5/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rhein SCHEMBL25253 | 0.98 | ALDH1A1 (1.00) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| Rhein SCHEMBL29404324 | 0.98 | ALDH1A1 (1.00) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| Rhein SCHEMBL8012677 | 0.97 | ALDH1A1 (0.97) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| Rhein SCHEMBL23632984 | 0.97 | ALDH1A1 (0.97) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| Rhein SCHEMBL1357918 | 0.97 | ALDH1A1 (0.97) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| Rhein SCHEMBL23632879 | 0.97 | ALDH1A1 (0.97) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| Rhein SCHEMBL23632868 | 0.97 | ALDH1A1 (0.97) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| Rhein SCHEMBL23633120 | 0.97 | ALDH1A1 (0.97) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| Rhein SCHEMBL1356821 | 0.97 | ALDH1A1 (0.97) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| Rhein SCHEMBL8618738 | 0.97 | ALDH1A1 (0.97) | ALDH1A1MAPTMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140163217-A1 | PROCESS FOR THE ESTERIFICATION OF HYALURONIC ACID WITH HYDROPHOBIC ORGANIC COMPOUNDS | UNIVERSITE DE GENEVE (CH) | 2014-06-12 | — | — | US | disclosed |
| EP-2598536-A1 | PROCESS FOR THE ESTERIFICATION OF HYALURONIC ACID WITH HYDROPHOBIC ORGANIC COMPOUNDS | Université de Genève (CH) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012013670-A1 | PROCESS FOR THE ESTERIFICATION OF HYALURONIC ACID WITH HYDROPHOBIC ORGANIC COMPOUNDS | UNIVERSITY OF GENEVA (CH) | 2012-02-02 | — | — | WO | disclosed |
| EP-1921091-B9 | Process for the preparation of esters of the diacerein with hyaluronic acid and pharmaceutical preparations containing them | CBB NET S A (CH) | 2009-11-18 | — | — | EP | disclosed |
| US-20090239822-A1 | Process for the preparation of esters of diacerein with hyaluronic acid and pharmaceutical compositions containing such esters | CBB NET S.,A. | 2009-09-24 | — | — | US | disclosed |
| EP-1921091-B1 | Process for the preparation of esters of the diacerein with hyaluronic acid and pharmaceutical preparations containing them | CBB NET S A (CH) | 2009-06-24 | — | — | EP | disclosed |
| EP-1921091-A1 | Process for the preparation of esters of the diacerein with hyaluronic acid and pharmaceutical preparations containing them | CBB Net S.A. (CH) | 2008-05-14 | — | — | EP | disclosed |
| EP-0588797-B1 | N- 4,5-DIHYDROXY- AND 4,5,8-TRIHYDROXY-9,10-DIHYDRO-9,10-DIOXO-2-ANTHRACENE-YL]CARBONYL]AMINO ACIDS USEFUL IN THE THERAPY OF OSTEOARTICULAR AFFECTIONS | GENTILI IST SPA (IT) | 1996-02-21 | — | — | EP | disclosed |
| US-5451606-A | Anthraquinone compounds useful to treat osteoarticular conditions, pharmaceutical compositions and method of treatment | ISTITUTO GENTILI S.P.A. (IT) | 1995-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239822-A1 | Process for the preparation of esters of diacerein with hyaluronic acid and pharmaceutical compositions containing such esters | LIPA, DDOST, IDE | TTR 1618/4885HSP90AA1 800/4885HSP90AB1 759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.