Sulfuric Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 CALCRL CHRM1 CHRM2 CHRM3 F2R MAOA MAOB MAP2K1 MAP2K2 NTRK1 NTRK2 NTRK3 OPRD1 OPRK1 OPRM1 P2RY12 PKLR SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SLC18A2 SLC6A2 SLC6A3 TLR7 TLR9 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 dacA dacB dacC folA ftsI mrcA mrcB mrdA pol rplA rplB rplC rplD rplE rplF rplI rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmB1 rpmB2 rpmC rpmD rpmE rpmE2 rpmF rpmG rpmG1 rpmG2 rpmH rpmI rpmJ rpmJ2 rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsR1 rpsR2 rpsS rpsT rpsU rpsZ ykgM ykgO

The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	ADORA1	P30542	3/20	0.39

▸	ADORA2A	P29274	2/20	0.39

▸	PDE3B	Q13370	2/20	0.36

▸	PDE3A	Q14432	2/20	0.36

▸	CA5A	P35218	2/20	0.35

▸	KDM4E	B2RXH2	2/20	0.34

▸	PNP	P00491	1/20	0.33

▸	CA12	O43570	1/20	0.33

▸	CA1	P00915	1/20	0.33

▸	CA3	P07451	1/20	0.33

▸	CA4	P22748	1/20	0.33

▸	CA6	P23280	1/20	0.33

▸	CA7	P43166	1/20	0.33

▸	CA9	Q16790	1/20	0.33

▸	CA13	Q8N1Q1	1/20	0.33

▸	CA14	Q9ULX7	1/20	0.33

▸	CA5B	Q9Y2D0	1/20	0.33

▸	CYP3A4	P08684	1/20	0.33

▸	BLM	P54132	1/20	0.33

▸	PARP1	P09874	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL3729985	0.91	ADORA1 (0.44)	ADORA1ADORA2APDE3BPDE3ACA5A
SCHEMBL587003	0.71	KMT2A (0.45)	ADORA1ADORA2APDE3BPDE3ACA5A
Cytosine SCHEMBL10411159	0.68	DYRK1A (0.38)	ADORA1ADORA2AKDM4EPNPCA1
SCHEMBL5076877	0.67	CA12 (0.42)	ADORA1ADORA2APDE3BPDE3ACA5A
SCHEMBL4136622	0.67	PDE3B (0.47)	ADORA1ADORA2APDE3BPDE3ACA5A
SCHEMBL11591796	0.67	ADORA1 (0.53)	ADORA1ADORA2ACA5AKDM4ECYP3A4
Sulfuric Acid SCHEMBL2243571	0.65	NOS2 (0.48)	KDM4ECYP3A4PLAUALDH1A1HSD17B10
SCHEMBL22719049	0.64	ADORA1 (0.42)	ADORA1ADORA2ACA5ACYP3A4BLM
Sulfuric Acid SCHEMBL31503134	0.64	CA12 (0.80)	PDE3BPDE3ACA5AKDM4ECA12
Sulfuric Acid SCHEMBL48929	0.64	CA12 (0.80)	PDE3BPDE3ACA5AKDM4ECA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20080167319-A1	7-(4-(4-[3-CHLORO-2-(TRIFLUOROMETHYL)PHENYL]PIPERAZIN-1-YL)BUTOXY)-[1,8]-NAPHTHYRIDIN-2(1H)-ONE	PFIZER INC.	2008-07-10	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20080167319-A1	7-(4-(4-[3-CHLORO-2-(TRIFLUOROMETHYL)PHENYL]PIPERAZIN-1-YL)BUTOXY)-[1,8]-NAPHTHYRIDIN-2(1H)-ONE	BDNF, SCN7A, GRIN2C	ADORA1 2423/4885ADORA2A 2887/4885PDE3B 1165/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.