Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 6/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HMGCR | P04035 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14540741 | 0.87 | FOLH1 (0.41) | TRPV1MEN1KMT2AFOLH1THRA | |
| SCHEMBL3137725 | 0.87 | FOLH1 (0.41) | TRPV1MEN1KMT2AFOLH1THRA | |
| SCHEMBL3146089 | 0.84 | PDK2 (0.48) | PDK2MEN1KMT2ALMNAHMGCR | |
| SCHEMBL4927284 | 0.77 | HPGD (0.43) | MEN1KMT2ATHRATHRBLMNA | |
| SCHEMBL14540985 | 0.74 | TRPV1 (0.37) | TRPV1MEN1KMT2AFOLH1THRA | |
| SCHEMBL16904222 | 0.73 | PDK2 (0.43) | PDK2MEN1KMT2APOLBLMNA | |
| SCHEMBL3911299 | 0.72 | FOLH1 (0.41) | TRPV1MEN1KMT2AFOLH1THRA | |
| SCHEMBL2164006 | 0.72 | FOLH1 (0.41) | TRPV1MEN1KMT2AFOLH1THRA | |
| SCHEMBL4817111 | 0.71 | FOLH1 (0.40) | TRPV1MEN1KMT2AFOLH1THRA | |
| SCHEMBL18822126 | 0.71 | THRB (0.47) | TRPV1MEN1KMT2AFOLH1THRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899309-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003419-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2007-01-11 | — | — | WO | disclosed |