Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HMGCR | P04035 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16904222 | 0.88 | PDK2 (0.43) | PDK2LMNAHMGCRPTGS2MAPT | |
| SCHEMBL5077496 | 0.84 | PDK2 (0.41) | PDK2LMNAHMGCRPTGS2MAPT | |
| SCHEMBL16097466 | 0.81 | LMNA (0.47) | PDK2LMNAPTGS2MAPTALDH1A1 | |
| SCHEMBL3927973 | 0.81 | GAA (0.53) | LMNAPTGS2MAPK1ALDH1A1KDM4E | |
| SCHEMBL21224752 | 0.81 | GAA (0.46) | PDK2LMNAPTGS2MAPK1KDM4E | |
| SCHEMBL9205800 | 0.79 | HSP90AB1 (0.50) | LMNAHMGCRPTGS2MAPTALDH1A1 | |
| SCHEMBL3138757 | 0.79 | ALOX15 (0.50) | LMNATSHRALDH1A1HSD17B10 | |
| SCHEMBL20424197 | 0.79 | LMNA (0.62) | LMNAPTGS2MAPTTSHRMAPK1 | |
| SCHEMBL13116437 | 0.79 | LMNA (0.57) | PDK2LMNAPTGS2MAPTTSHR | |
| SCHEMBL23927461 | 0.78 | SMN1; SMN2 (0.54) | LMNAPTGS2MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004271-A1 | HETEROCYCLIC COMPOUNDS AS AGANIST FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004271-A1 | HETEROCYCLIC COMPOUNDS AS AGANIST FOR THE THYROID RECEPTOR | TSHR, GHSR, TRHR | PDK2 2832/4885LMNA 3371/4885HMGCR 749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.