Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14540741 | 1.00 | FOLH1 (0.41) | FOLH1PTPN1ESR1TRPV1ESR2 | |
| SCHEMBL5077496 | 0.87 | PDK2 (0.41) | FOLH1TRPV1GAAMAPTTHRA | |
| SCHEMBL4927284 | 0.85 | HPGD (0.43) | MAPTTHRATHRBMEN1KMT2A | |
| SCHEMBL2164006 | 0.83 | FOLH1 (0.41) | FOLH1PTPN1ESR1TRPV1ESR2 | |
| SCHEMBL3911299 | 0.83 | FOLH1 (0.41) | FOLH1PTPN1ESR1TRPV1ESR2 | |
| SCHEMBL6374059 | 0.82 | THRB (0.47) | FOLH1ESR1TRPV1MAPTTHRA | |
| SCHEMBL4817111 | 0.82 | FOLH1 (0.40) | FOLH1PTPN1ESR1TRPV1ESR2 | |
| SCHEMBL18822126 | 0.82 | THRB (0.47) | FOLH1ESR1TRPV1MAPTTHRA | |
| SCHEMBL7275974 | 0.82 | THRB (0.47) | FOLH1ESR1TRPV1MAPTTHRA | |
| SCHEMBL14540982 | 0.81 | PTPN1 (0.44) | FOLH1PTPN1ESR1MAPTTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004271-A1 | HETEROCYCLIC COMPOUNDS AS AGANIST FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2010-01-07 | — | — | US | disclosed |
| US-20090318514-A1 | Novel Pharmaceutical Compositions | KARO BIO AB (SE) | 2009-12-24 | — | — | US | disclosed |
| US-20090233979-A1 | Indole Derivatives and Their Use as Thyroid Receptor Ligands | KARO BIO AB (SE) | 2009-09-17 | — | — | US | disclosed |
| EP-2024336-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2009-02-18 | — | — | EP | disclosed |
| US-20080221210-A1 | Thyroid Receptor Agonists | KARO BIO AB (SE) | 2008-09-11 | — | — | US | disclosed |
| WO-2007128492-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2007-11-15 | — | — | WO | disclosed |
| WO-2007039125-A2 | AN OPTICALLY ACTIVE THYROID RECEPTOR AGONIST AND OPTICALLY ACTIVE KEY INTERMEDIATES IN ITS PRODUCTION | KARO BIO AB (SE) | 2007-04-12 | — | — | WO | disclosed |
| EP-1732533-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092317-A1 | THYROID RECEPTOR AGONISTS | KARO BIO AB (SE) | 2005-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233979-A1 | Indole Derivatives and Their Use as Thyroid Receptor Ligands | TSHR, TRHR, THRA | FOLH1 4129/4885PTPN1 1254/4885ESR1 216/4885 |
| US-20080221210-A1 | Thyroid Receptor Agonists | TSHR, TRHR, THRA | FOLH1 3834/4885PTPN1 354/4885ESR1 246/4885 |
| US-20100004271-A1 | HETEROCYCLIC COMPOUNDS AS AGANIST FOR THE THYROID RECEPTOR | TSHR, GHSR, TRHR | FOLH1 3066/4885PTPN1 924/4885ESR1 269/4885 |
| US-20090318514-A1 | Novel Pharmaceutical Compositions | TSHR, TRHR, THRA | FOLH1 3224/4885PTPN1 1294/4885ESR1 288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.