Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5074722 | 0.86 | ALDH1A1 (0.40) | MAPTALDH1A1L3MBTL1PDE10ACYP1A2 | |
| SCHEMBL15173231 | 0.76 | MAPT (0.41) | MAPTALDH1A1L3MBTL1MAPK1CYP1A2 | |
| SCHEMBL16097654 | 0.72 | PDE10A (0.38) | MAPTALDH1A1L3MBTL1PDE10AMAPK1 | |
| Hydrochloric Acid SCHEMBL11734144 | 0.72 | TDP1 (0.41) | MAPTALDH1A1LMNATDP1MEN1 | |
| SCHEMBL28393356 | 0.70 | TDP1 (0.39) | MAPTALDH1A1LMNAKDM4ETDP1 | |
| SCHEMBL5075152 | 0.70 | ALDH1A1 (0.51) | MAPTALDH1A1L3MBTL1PDE10AMAPK1 | |
| SCHEMBL15173205 | 0.70 | MAPT (0.46) | MAPTALDH1A1L3MBTL1POLBLMNA | |
| SCHEMBL29508937 | 0.69 | PDE10A (0.56) | MAPTALDH1A1L3MBTL1PDE10AMAPK1 | |
| SCHEMBL251800 | 0.69 | PDE10A (0.56) | MAPTALDH1A1L3MBTL1PDE10AMAPK1 | |
| SCHEMBL29077094 | 0.68 | KMT2A (0.41) | MAPTALDH1A1L3MBTL1MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996585-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007109154-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |