Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5077937 | 0.86 | MAPT (0.45) | ALDH1A1MAPTL3MBTL1PDE10APOLB | |
| SCHEMBL16097654 | 0.72 | PDE10A (0.38) | ALDH1A1MAPTL3MBTL1PAX8PDE10A | |
| Hydrochloric Acid SCHEMBL11734144 | 0.72 | TDP1 (0.41) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL15173231 | 0.71 | MAPT (0.41) | ALDH1A1MAPTL3MBTL1CYP1A2CYP2C9 | |
| SCHEMBL28393356 | 0.70 | TDP1 (0.39) | ALDH1A1MAPTLMNAMEN1KMT2A | |
| SCHEMBL5075152 | 0.70 | ALDH1A1 (0.51) | ALDH1A1MAPTL3MBTL1PDE10APOLB | |
| SCHEMBL1232447 | 0.69 | PAX8 (0.58) | ALDH1A1MAPTPAX8PDE10APOLB | |
| SCHEMBL30425291 | 0.69 | PAX8 (0.58) | ALDH1A1MAPTPAX8PDE10APOLB | |
| SCHEMBL29077094 | 0.68 | KMT2A (0.41) | ALDH1A1MAPTL3MBTL1RAB9ALMNA | |
| SCHEMBL15173205 | 0.67 | MAPT (0.46) | ALDH1A1MAPTL3MBTL1POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996585-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007109154-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |