Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 2/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1232253 | 1.00 | LMNA (0.46) | LMNACYP1A2CYP3A4MAOATSHR | |
| SCHEMBL28889391 | 1.00 | LMNA (0.46) | LMNACYP1A2CYP3A4MAOATSHR | |
| SCHEMBL5078448 | 0.88 | CYP1A2 (0.46) | LMNACYP1A2CYP3A4MAOATSHR | |
| SCHEMBL21291549 | 0.88 | CYP1A2 (0.46) | LMNACYP1A2CYP3A4MAOATSHR | |
| SCHEMBL5084405 | 0.86 | ALDH1A1 (0.44) | LMNATSHRMAPTALDH1A1GAA | |
| SCHEMBL5084403 | 0.86 | ALDH1A1 (0.44) | LMNATSHRMAPTALDH1A1GAA | |
| SCHEMBL28889387 | 0.85 | LMNA (0.41) | LMNACYP1A2CYP3A4MAOATSHR | |
| SCHEMBL28889389 | 0.85 | LMNA (0.44) | LMNACYP1A2CYP3A4MAOATSHR | |
| SCHEMBL28889419 | 0.85 | LMNA (0.41) | LMNACYP1A2CYP3A4MAOATSHR | |
| Hydrochloric Acid SCHEMBL31375791 | 0.85 | ALDH1A1 (0.42) | LMNATSHRMAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115138353-A | Carbon source coated monolithic catalyst and preparation method and application thereof | 横店集团东磁股份有限公司 | 2022-10-04 | — | — | CN | claimed |
| WO-2019161963-A1 | METHOD AND KIT FOR ISOTOPE-LABELLING OF A FOLATE-CONTAINING BIOLOGICAL SAMPLE FOR MASS SPECTROMETRY | MEDIZINISCHE UNIVERSITÄT GRAZ (AT) | 2019-08-29 | — | — | WO | disclosed |
| EP-3530661-A1 | METHOD AND KIT FOR ISOTOPE-LABELLING OF A FOLATE-CONTAINING BIOLOGICAL SAMPLE FOR MASS SPECTROMETRY | Medizinische Universität Graz (AT) | 2019-08-28 | — | — | EP | disclosed |
| EP-1917027-A2 | CLEAVAGE OF ANTIFOLATE COMPOUNDS | Protherics Medicines Development Limited (GB) | 2008-05-07 | — | — | EP | disclosed |
| US-20070243182-A1 | Use of Carboxypeptidease G for Combating Antifolate Toxicity | PROTHERICS MEDICINES DEVELOPMENT LIMITED (GB) | 2007-10-18 | — | — | US | disclosed |
| WO-2007023243-A2 | CLEAVAGE OF ANTIFOLATE COMPOUNDS | PROTHERICS MEDICINES DEVELOPMENT LIMITED (GB) | 2007-03-01 | — | — | WO | disclosed |
| EP-1727548-A2 | USE OF CARBOXYPEPTIDASE G FOR COMBATING ANTIFOLATE TOXICITY | Protherics Medicines Development Limited (GB) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005084695-A2 | USE OF CARBOXYPEPTIDASE G FOR COMBATING ANTIFOLATE TOXICITY | PROTHERICS MEDICINES DEVELOPMENT LIMITED (GB) | 2005-09-15 | — | — | WO | disclosed |
| US-6887467-B1 | Double mutants of dihydrofolate reductase and methods of using same | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2005-05-03 | — | — | US | disclosed |
| US-6642043-B1 | Substituting amino acid side chains where on has larger volume and the other is hydrophilic; use in producing drug resistant bone marrow or peripheral stem cells | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2003-11-04 | — | — | US | disclosed |
| US-6127150-A | VECTOR FOR THE EFFICIENT EXPRESSION AND ISOLATION OF HETEROLOGOUS PROTEINS | BIONEBRASKA, INC. (US) | 2000-10-03 | — | — | US | disclosed |
| WO-1997033988-A1 | DOUBLE MUTANTS OF DIHYDROFOLATE REDUCTASE AND METHODS OF USING SAME | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1997-09-18 | — | — | WO | disclosed |
| US-5595887-A | GENE EXPRESSION, FORMING POLYPEPTIDES FOR PROTEIN PURIFICATION | BIONEBRASKA, INC. (US) | 1997-01-21 | — | — | US | disclosed |
| EP-0539530-A4 | PURIFICATION DIRECTED CLONING OF PEPTIDES. | — | 1993-09-15 | — | — | EP | disclosed |
| EP-0539530-A1 | PURIFICATION DIRECTED CLONING OF PEPTIDES | BIONEBRASKA, INC. (US) | 1993-05-05 | — | — | EP | disclosed |
| WO-1992001707-A1 | PURIFICATION DIRECTED CLONING OF PEPTIDES | BIONEBRASKA, INC. (US) | 1992-02-06 | — | — | WO | disclosed |
| EP-0007917-B1 | IMPROVEMENTS IN OR RELATING TO MEDIA FOR AFFINITY CHROMATOGRAPHY | THE SECRETARY OF STATE FOR DEFENCE (GB) | 1984-02-01 | — | — | EP | disclosed |
| US-4136101-A | PROCESS FOR PREPARING DIALKYL (P-AMINOBENZOYL) GLUTAMATES | AMERICAN CYANAMID COMPANY (US) | 1979-01-23 | — | — | US | disclosed |
| US-4080325-A | REACTING TETRAAMINOPYRIMIDINE HYDROCHLORIDE WITH DIHYDROXYACETONE, MULTISTAGE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE | 1978-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070243182-A1 | Use of Carboxypeptidease G for Combating Antifolate Toxicity | CPB1, FOLH1, CPA1 | LMNA 3735/4885CYP1A2 1000/4885CYP3A4 1647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.