Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.31 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 4/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5082157 | 0.89 | IGF1R (0.38) | RAB9ANPC1PRKDCSRCPDGFRB | |
| SCHEMBL5083550 | 0.88 | IGF1R (0.40) | RAB9ANPC1PDGFRBKITFLT3 | |
| SCHEMBL5082928 | 0.86 | IGF1R (0.40) | TNK2CYP3A4IGF1RMAPK1 | |
| SCHEMBL5086159 | 0.86 | TNK2 (0.35) | TNK2CYP3A4IGF1RGAAKDM4E | |
| SCHEMBL5082839 | 0.79 | TNK2 (0.41) | TNK2KDM4EALDH1A1HPGD | |
| SCHEMBL5083767 | 0.78 | IGF1R (0.46) | RAB9ANPC1SRCPDGFRBKIT | |
| SCHEMBL5084929 | 0.77 | IGF1R (0.47) | RAB9ANPC1FLT3TNK2CYP3A4 | |
| SCHEMBL5083969 | 0.75 | IGF1R (0.46) | TNK2CYP3A4IGF1RMAPK1 | |
| SCHEMBL5081943 | 0.73 | IGF1R (0.35) | KITCYP3A4IGF1RKDM4EMAPT | |
| SCHEMBL401395 | 0.73 | IGF1R (0.62) | TNK2CYP3A4IGF1RFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |