Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 18/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5086596 | 0.89 | TNK2 (0.42) | TNK2LMNAL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL5085497 | 0.88 | TNK2 (0.44) | TNK2LMNAL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL5078897 | 0.88 | TNK2 (0.40) | TNK2 | |
| SCHEMBL5082928 | 0.85 | IGF1R (0.40) | TNK2 | |
| SCHEMBL5086159 | 0.83 | TNK2 (0.35) | TNK2LMNAKDM4EALDH1A1HPGD | |
| SCHEMBL5080265 | 0.79 | RAB9A (0.35) | TNK2KDM4EALDH1A1HPGD | |
| SCHEMBL5083250 | 0.79 | TNK2 (0.45) | TNK2 | |
| SCHEMBL13504863 | 0.78 | TNK2 (0.53) | TNK2 | |
| SCHEMBL5083969 | 0.74 | IGF1R (0.46) | TNK2 | |
| SCHEMBL5081943 | 0.74 | IGF1R (0.35) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |