SCHEMBL5080754

SCHEMBL5080754

O=C(O)CCc1c2ccc(=O)c(O)c-2oc2c(O)c(O)ccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 6/20 1.00
ALOX15 P16050 6/20 1.00
HSD17B10 Q99714 6/20 1.00
HSPA1A P0DMV8 4/20 1.00
HSPA8 P11142 4/20 1.00
BRCA1 P38398 3/20 1.00
ALDH1A1 P00352 3/20 1.00
HIF1A Q16665 2/20 1.00
CDC25A P30304 1/20 1.00
CDC25B P30305 1/20 1.00
STAT6 P42226 1/20 1.00
GNG2 P59768 9/20 0.56
GNB1 P62873 9/20 0.56
CYP2C9 P11712 4/20 0.56
CYP2C19 P33261 4/20 0.56
MAPK1 P28482 2/20 0.56
GAPDH P04406 1/20 0.56
RAPGEF4 Q8WZA2 1/20 0.56
CYP1A2 P05177 2/20 0.53
TSHR P16473 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29986877 1.00 HPGD (1.00) HPGDALOX15HSD17B10HSPA1AHSPA8
SCHEMBL21479633 0.89 ALOX15 (0.80) HPGDALOX15HSD17B10HSPA1AHSPA8
SCHEMBL13771874 0.87 HPGD (0.77) HPGDALOX15HSD17B10HSPA1AHSPA8
SCHEMBL23386706 0.85 ALOX15 (0.74) HPGDALOX15HSD17B10HSPA1AHSPA8
SCHEMBL23386748 0.83 ALOX15 (0.70) HPGDALOX15HSD17B10HSPA1AHSPA8
SCHEMBL21479634 0.82 ALOX15 (0.70) HPGDALOX15HSD17B10HSPA1AHSPA8
SCHEMBL12051949 0.80 ALOX15 (0.66) HPGDALOX15HSD17B10HSPA1AHSPA8
SCHEMBL10911989 0.79 HPGD (0.65) HPGDALOX15HSD17B10HSPA1AHSPA8
SCHEMBL13352283 0.72 GNG2 (0.71) HPGDALOX15HSD17B10HSPA1AHSPA8
SCHEMBL2846330 0.72 GNG2 (1.00) HPGDALOX15HSD17B10HSPA1AHSPA8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080306031-A1 Methods of Inhibiting Poxvirus Growth SALK INSTITUTE FOR BIOLOGICAL STUDIES 2008-12-11 US claimed
WO-2007047339-A2 METHODS OF INHIBITING POXVIRUS GROWTH THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2007-04-26 WO claimed
US-5877210-A CONTROLLING IMMUNE RESPONSE BRISTOL-MYERS SQUIBB COMPANY (US) 1999-03-02 US claimed
US-5583242-A VANADYL COMPLEXES BRISTOL-MYERS SQUIBB COMPANY (US) 1996-12-10 US claimed
US-20250269043-A1 TARGETED BIFUNCTIONAL DEGRADERS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2025-08-28 US disclosed
EP-4493221-A2 TARGETED BIFUNCTIONAL DEGRADERS Yale University (US) 2025-01-22 EP disclosed
WO-2023178199-A2 TARGETED BIFUNCTIONAL DEGRADERS YALE UNIVERSITY (US) 2023-09-21 WO disclosed
US-20230241078-A1 Vanadyl and vanadate for use in reducing stress-induced metabolic derangement CFM PHARMA HOLDING B.V. (NL) 2023-08-03 US disclosed
US-20230087994-A1 TARGETED BIFUNCTIONAL DEGRADERS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2023-03-23 US disclosed
CN-115315272-A Targeting difunctional degradation agent 耶鲁大学 2022-11-08 CN disclosed
EP-4041262-A1 TARGETED BIFUNCTIONAL DEGRADERS Yale University (US) 2022-08-17 EP disclosed
WO-2021072269-A1 TARGETED BIFUNCTIONAL DEGRADERS YALE UNIVERSITY (US) 2021-04-15 WO disclosed
US-20080306031-A1 Methods of Inhibiting Poxvirus Growth SALK INSTITUTE FOR BIOLOGICAL STUDIES 2008-12-11 US disclosed
WO-2007047339-A2 METHODS OF INHIBITING POXVIRUS GROWTH THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2007-04-26 WO disclosed
US-5877210-A CONTROLLING IMMUNE RESPONSE BRISTOL-MYERS SQUIBB COMPANY (US) 1999-03-02 US disclosed
US-5846998-A Use of phosphotyrosine phosphatase inhibitors or phosphotyrosine kinase activators for controlling cellular proliferation BRISTOL-MYERS SQUIBB COMPANY (US) 1998-12-08 US disclosed
US-5693627-A TREATING DISEASES SUCH AS LEUKEMIAS AND LYMPHOMAS BRISTOL-MYERS SQUIBB COMPANY (US) 1997-12-02 US disclosed
US-5583242-A VANADYL COMPLEXES BRISTOL-MYERS SQUIBB COMPANY (US) 1996-12-10 US disclosed
US-5565491-A FOR TREATMENT OF DISEASES MARKED BY MALIGNANT PROLIFERATION OF B CELLS, SUCH AS LEUKEMIA AND LYMPHOMAS; ANTICARCINOGENIC AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 1996-10-15 US disclosed
WO-1995020390-A1 USE OF VANADIUM MOLYBDENUM OR TUNGSTEN COMPLEXES FOR CONTROLLING CELLULAR PROLIFERATION BRISTOL-MYERS SQUIBB COMPANY (US) 1995-08-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250269043-A1 TARGETED BIFUNCTIONAL DEGRADERS SMURF2, SMURF1, MDM2 HPGD 4489/4885ALOX15 4328/4885HSD17B10 4149/4885
US-20230087994-A1 TARGETED BIFUNCTIONAL DEGRADERS SMURF2, SMURF1, SSB HPGD 4608/4885ALOX15 4388/4885HSD17B10 4132/4885
US-20080306031-A1 Methods of Inhibiting Poxvirus Growth TTK, TXK, DCK HPGD 2912/4885ALOX15 3963/4885HSD17B10 2899/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.