Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | PDE6D | O43924 | 1/20 | 0.32 |
| ▸ | PDE6A | P16499 | 1/20 | 0.32 |
| ▸ | PDE6G | P18545 | 1/20 | 0.32 |
| ▸ | PDE6B | P35913 | 1/20 | 0.32 |
| ▸ | PDE6C | P51160 | 1/20 | 0.32 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27703070 | 0.89 | GPBAR1 (0.36) | GPBAR1PDE3BPDE3ACHRM5HTR1A | |
| SCHEMBL4762623 | 0.81 | CHRM1 (0.32) | PDE3BPDE3A | |
| SCHEMBL5583754 | 0.81 | NOTUM (0.34) | GPBAR1HSD11B1 | |
| SCHEMBL4596883 | 0.80 | GPBAR1 (0.37) | GPBAR1HTR1AHTR7 | |
| SCHEMBL4713338 | 0.80 | GPBAR1 (0.34) | GPBAR1PDE3BPDE3A | |
| SCHEMBL27703057 | 0.80 | TACR1 (0.37) | GPBAR1CHRM5HSD11B1TACR1 | |
| SCHEMBL4712286 | 0.80 | TACR1 (0.38) | GPBAR1TACR1 | |
| SCHEMBL4960255 | 0.80 | CETP (0.35) | GPBAR1PDE3BPDE3ACHRM5 | |
| SCHEMBL6374163 | 0.79 | BCAT1 (0.33) | PDE3BPDE3AHTR1AHTR7 | |
| SCHEMBL27703048 | 0.78 | HTR1A (0.36) | PDE3BPDE3AHTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1998764-A2 | METHODS FOR TREATING COGNITIVE AND OTHER DISORDERS | Wyeth a Corporation of the State of Delaware (US) | 2008-12-10 | — | — | EP | claimed |
| WO-2007112065-A2 | METHODS FOR TREATING COGNITIVE AND OTHER DISORDERS | WYETH (US) | 2007-10-04 | — | — | WO | claimed |