Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
| ▸ | GABRE | P78334 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27703070 | 0.86 | GPBAR1 (0.36) | EPHX2GPBAR1 | |
| SCHEMBL27703057 | 0.84 | TACR1 (0.37) | GPBAR1ARHSD11B1 | |
| SCHEMBL4712286 | 0.84 | TACR1 (0.38) | GPBAR1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL27723637 | 0.81 | GPBAR1 (0.38) | GPBAR1ARGABRPGABRDGABRA1 | |
| SCHEMBL28772994 | 0.81 | DPP4 (0.36) | CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL5080947 | 0.81 | GPBAR1 (0.35) | GPBAR1HSD11B1 | |
| SCHEMBL4596883 | 0.80 | GPBAR1 (0.37) | GPBAR1 | |
| SCHEMBL27703072 | 0.78 | TDP2 (0.38) | CYP1A2CYP2C19PIK3CA | |
| SCHEMBL5583570 | 0.77 | HTR1A (0.41) | NOTUM | |
| SCHEMBL4713338 | 0.76 | GPBAR1 (0.34) | GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101448492-A | Methods of treating cognitive and other disorders | WYETH CORP (US) | 2009-06-03 | — | — | CN | claimed |
| CN-101389325-A | Treatment of drug abuse | WYETH CORP (US) | 2009-03-18 | — | — | CN | claimed |
| CN-101203217-A | Methods for modulating bladder function | WYETH CORP (US) | 2008-06-18 | — | — | CN | claimed |
| CN-101203216-A | Dihydrobenzofuran derivatives and uses thereof | WYETH CORP (US) | 2008-06-18 | — | — | CN | claimed |
| CN-101198322-A | Novel therapeutic combinations for the treatment or prevention of depression | WYETH CORP (US) | 2008-06-11 | — | — | CN | claimed |
| CN-101198323-A | Therapeutic combinations for the treatment or prevention of psychotic disorders | WYETH CORP (US) | 2008-06-11 | — | — | CN | claimed |
| CN-101189004-A | Treatment of pain | WYETH CORP (US) | 2008-05-28 | — | — | CN | claimed |
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |
| CN-101448492-A | Methods of treating cognitive and other disorders | WYETH CORP (US) | 2009-06-03 | — | — | CN | disclosed |
| CN-101389325-A | Treatment of drug abuse | WYETH CORP (US) | 2009-03-18 | — | — | CN | disclosed |
| CN-101203217-A | Methods for modulating bladder function | WYETH CORP (US) | 2008-06-18 | — | — | CN | disclosed |
| CN-101203216-A | Dihydrobenzofuran derivatives and uses thereof | WYETH CORP (US) | 2008-06-18 | — | — | CN | disclosed |
| CN-101198322-A | Novel therapeutic combinations for the treatment or prevention of depression | WYETH CORP (US) | 2008-06-11 | — | — | CN | disclosed |
| CN-101198323-A | Therapeutic combinations for the treatment or prevention of psychotic disorders | WYETH CORP (US) | 2008-06-11 | — | — | CN | disclosed |
| CN-101189004-A | Treatment of pain | WYETH CORP (US) | 2008-05-28 | — | — | CN | disclosed |