Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.30 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.30 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4960255 | 0.89 | CETP (0.35) | GPBAR1PDE3BPDE3A | |
| SCHEMBL27703070 | 0.84 | GPBAR1 (0.36) | GPBAR1PDE3BPDE3A | |
| SCHEMBL4762814 | 0.83 | NTRK1 (0.32) | TDP2PDE3BPDE3A | |
| SCHEMBL4964977 | 0.80 | TDP2 (0.33) | TDP2PDE3BPDE3A | |
| SCHEMBL27703048 | 0.80 | HTR1A (0.36) | CYP11B2PDE3BPDE3A | |
| SCHEMBL5080947 | 0.80 | GPBAR1 (0.35) | GPBAR1PDE3BPDE3A | |
| SCHEMBL4794338 | 0.77 | MAPK14 (0.41) | TDP2 | |
| SCHEMBL27703072 | 0.77 | TDP2 (0.38) | TDP2POLBMAPT | |
| SCHEMBL5583754 | 0.76 | NOTUM (0.34) | GPBAR1 | |
| SCHEMBL4712609 | 0.76 | GPBAR1 (0.35) | GPBAR1CYP11B2CYP11B1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |
| EP-1874292-A2 | METHODS FOR MODULATING BLADDER FUNCTION | Wyeth (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006116169-A2 | METHODS FOR MODULATING BLADDER FUNCTION | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |