Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 11/20 | 0.42 |
| ▸ | IGF1R | P08069 | 3/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.32 |
| ▸ | MCHR2 | Q969V1 | 2/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.31 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.31 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.31 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.31 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5084882 | 0.88 | IGF1R (0.48) | TNK2IGF1R | |
| SCHEMBL5085414 | 0.87 | TNK2 (0.38) | TNK2 | |
| SCHEMBL5087010 | 0.85 | IGF1R (0.39) | TNK2IGF1RPIK3CGPIK3CDPIK3R2 | |
| SCHEMBL5085373 | 0.85 | IGF1R (0.43) | TNK2IGF1RPIK3CGABL1PIK3CA | |
| SCHEMBL5082589 | 0.82 | IGF1R (0.41) | TNK2IGF1RABL1 | |
| SCHEMBL401937 | 0.79 | TNK2 (0.41) | TNK2IGF1RPIK3CGPIK3CDPIK3R2 | |
| SCHEMBL401938 | 0.79 | TNK2 (0.65) | TNK2IGF1RPIK3CGPIK3CAPIK3CB | |
| SCHEMBL5086253 | 0.79 | TNK2 (0.50) | TNK2IGF1RKLKB1ABL1 | |
| SCHEMBL5086140 | 0.78 | TNK2 (0.45) | TNK2IGF1R | |
| SCHEMBL5081320 | 0.73 | TNK2 (0.44) | TNK2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979002-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |
| WO-2007075554-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |