Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.33 |
| ▸ | PLA2G4A | P47712 | 3/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL11410602 | 0.81 | S1PR1 (0.39) | KDM4EMEN1LMNAKMT2AALDH1A1 | |
| Tromethamine SCHEMBL22472039 | 0.81 | S1PR1 (0.39) | POLBMEN1LMNAKMT2AALDH1A1 | |
| Tromethamine SCHEMBL18614041 | 0.81 | CA1 (0.41) | MEN1KMT2APARP10AOC3 | |
| Ethylene Glycol SCHEMBL16822397 | 0.81 | ALDH1A1 (0.48) | MEN1LMNAKMT2AALDH1A1RECQL | |
| SCHEMBL126344 | 0.81 | LTA4H (0.45) | LMNAALDH1A1RECQLLTA4H | |
| SCHEMBL30275406 | 0.81 | LTA4H (0.45) | LMNAALDH1A1RECQLLTA4H | |
| SCHEMBL11676343 | 0.81 | ALDH1A1 (0.36) | LMNAALDH1A1RECQLLTA4H | |
| SCHEMBL6069163 | 0.81 | ALDH1A1 (0.36) | LMNAALDH1A1RECQLLTA4H | |
| SCHEMBL23754601 | 0.79 | LTA4H (0.43) | LMNAALDH1A1RECQLLTA4H | |
| SCHEMBL1160536 | 0.79 | LTA4H (0.43) | LMNAALDH1A1RECQLLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303803-A1 | ANTI-AGEING ADDITIVES FOR BITUMEN | SHELL USA, INC. | 2023-09-28 | — | — | US | claimed |
| EP-4189004-A1 | ANTI-AGEING ADDITIVES FOR BITUMEN | Shell Internationale Research Maatschappij B.V. (NL) | 2023-06-07 | — | — | EP | claimed |
| WO-2022023531-A1 | ANTI-AGEING ADDITIVES FOR BITUMEN | SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) | 2022-02-03 | — | — | WO | claimed |
| US-4067933-A | OXIDATION RESISTANCE | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1978-01-10 | — | — | US | claimed |
| US-3959221-A | OXIDATIVE DEGRADATION | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1976-05-25 | — | — | US | claimed |
| JP-58180553-A | — | — | None | — | — | JP | disclosed |
| EP-4702063-A1 | LINEAR HIGH-DENSITY POLYETHYLENE COMPOSITION SUITABLE FOR INTERMEDIATE BULK CONTAINER APPLICATIONS | Nova Chemicals (International) S.A. (CH) | 2026-03-04 | — | — | EP | disclosed |
| EP-4702062-A1 | LINEAR HIGH-DENSITY POLYETHYLENE COMPOSITION AND ROTOMOLDED ARTICLE | Nova Chemicals (International) S.A. (CH) | 2026-03-04 | — | — | EP | disclosed |
| EP-4702064-A1 | POLYMERIZATION PROCESS, HDPE POLYETHYLENE COMPOSITION AND ROTOMOLDED ARTICLE | Nova Chemicals (International) S.A. (CH) | 2026-03-04 | — | — | EP | disclosed |
| US-12351704-B2 | Use of recycled polyethylene in closures for bottles | NOVA CHEMICALS (INTERNATIONAL) S.A. (CH) | 2025-07-08 | — | — | US | disclosed |
| EP-4045589-B1 | USE OF RECYCLED POLYETHYLENE IN CLOSURES FOR BOTTLES | NOVA CHEM INT SA (CH) | 2024-11-27 | — | — | EP | disclosed |
| WO-2024224250-A1 | LINEAR HIGH-DENSITY POLYETHYLENE COMPOSITION AND ROTOMOLDED ARTICLE | NOVA CHEMICALS (INTERNATIONAL) S.A. (CH) | 2024-10-31 | — | — | WO | disclosed |
| US-20180186942-A1 | MIXED PHOSPHITE STABILIZATION OF POLYETHYLENE FILM | NOVA CHEMICALS (INTERNATIONAL) S.A. (CH) | 2018-07-05 | — | — | US | disclosed |
| US-7361703-B2 | Incorporating an aryl monophosphite and a diphosphite (distearyl pentaerythritol diphosphite) in a linear ethylene polymer that contains titanium, vanadium, zirconium or chromium; free of hindered phenolic antioxidants, lactone stabilizers and hydroxylamine stabilizers | NOVA CHEMICAL (INTERNATIONAL) S.A. (CH) | 2008-04-22 | — | — | US | disclosed |
| US-20050261403-A1 | Phenol free stabilization of polyethylene film | NOVA CHEMICALS (INTERNATIONAL) S.A. | 2005-11-24 | — | — | US | disclosed |
| WO-2005111139-A1 | PHENOL FREE STABILIZATION OF POLYETHYLENE FILM | NOVA CHEMICALS (INTERNATIONAL) S.A. (CH) | 2005-11-24 | — | — | WO | disclosed |
| JP-S58180553-A | MOLDING MATERIAL FOR OPTICAL INSTRUMENT | IDEMITSU PETROCHEM CO LTD | 1983-10-22 | — | — | JP | disclosed |
| US-4407995-A | HEAT RESISTANCE, DISCOLORATION INHIBITION | THE DOW CHEMICAL COMPANY (US) | 1983-10-04 | — | — | US | disclosed |
| US-4067933-A | OXIDATION RESISTANCE | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1978-01-10 | — | — | US | disclosed |
| US-3959221-A | OXIDATIVE DEGRADATION | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1976-05-25 | — | — | US | disclosed |