Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 known ✓ | P03956 | 1/20 | 0.59 |
| ▸ | MMP8 known ✓ | P22894 | 1/20 | 0.59 |
| ▸ | MMP13 known ✓ | P45452 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | MMP2 | P08253 | 1/20 | 0.59 |
| ▸ | MMP9 | P14780 | 1/20 | 0.59 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PKLR | P30613 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.47 |
| ▸ | APLNR | P35414 | 1/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Silver SCHEMBL6114468 | 0.96 | CA1 (0.59) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL5400958 | 0.88 | CA1 (0.51) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL5403735 | 0.85 | CA1 (0.49) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL5398505 | 0.84 | FFAR1 (0.55) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL29594358 | 0.82 | CA1 (0.45) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL30859041 | 0.82 | CA1 (0.65) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL8863056 | 0.82 | CA1 (0.65) | CA1CA2MMP1MMP2MMP9 | |
| Toliodium SCHEMBL5398408 | 0.82 | FFAR1 (0.52) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL5400807 | 0.81 | FFAR1 (0.51) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL5404728 | 0.81 | CA1 (0.44) | CA1CA2MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8975367-B2 | Polyphosphonate and copolyphosphonate additive mixtures | FRX POLYMERS, INC. (US) | 2015-03-10 | — | — | US | claimed |
| EP-3365168-B1 | LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES | SCHNELLER LLC (US) | 2021-06-30 | — | — | EP | disclosed |
| US-20200338873-A1 | LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES | SCHNELLER LLC (US) | 2020-10-29 | — | — | US | disclosed |
| EP-3365168-A1 | LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES | Schneller, LLC (US) | 2018-08-29 | — | — | EP | disclosed |
| WO-2017070276-A1 | LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES | SCHNELLER LLC (US) | 2017-04-27 | — | — | WO | disclosed |
| US-20170113445-A1 | LIGHTWEIGHT FLAME RETARDANT THERMOPLASTIC STRUCTURES | SCHNELLER LLC | 2017-04-27 | — | — | US | disclosed |
| US-9527984-B2 | Polyphosphonate and copolyphosphonate additive mixtures | FRX POLYMERS, INC. (US) | 2016-12-27 | — | — | US | disclosed |
| US-9267017-B2 | Thermoplastic polyurethanes with exceptional fire resistance | FRX POLYMERS, INC. (US) | 2016-02-23 | — | — | US | disclosed |
| US-20150175777-A1 | POLYPHOSPHONATE AND COPOLYPHOSPHONATE ADDITIVE MIXTURES | FRX POLYMERS, INC. (US) | 2015-06-25 | — | — | US | disclosed |
| US-8975367-B2 | Polyphosphonate and copolyphosphonate additive mixtures | FRX POLYMERS, INC. (US) | 2015-03-10 | — | — | US | disclosed |
| US-20130046036-A1 | THERMOPLASTIC POLYURETHANES WITH EXCEPTIONAL FIRE RESISTANCE | FRX POLYMERS, INC. (US) | 2013-02-21 | — | — | US | disclosed |
| US-20120264844-A1 | POLYPHOSPHONATE AND COPOLYPHOSPHONATE ADDITIVE MIXTURES | FRX POLYMERS, INC. (US) | 2012-10-18 | — | — | US | disclosed |
| WO-2012142596-A2 | POLYPHOSPHONATE AND COPOLYPHOSPHONATE ADDITIVE MIXTURES | FRX POLYMERS, INC. (US) | 2012-10-18 | — | — | WO | disclosed |
| EP-1497374-B1 | FILLER REINFORCED POLYETHER IMIDE RESIN COMPOSITION AND MOLDED ARTICLE THEREOF | GEN ELECTRIC (US) | 2008-08-13 | — | — | EP | disclosed |
| US-7244778-B2 | Filler reinforced polyether imide resin composition and molded article thereof | GENERAL ELECTRIC COMPANY (US) | 2007-07-17 | — | — | US | disclosed |
| CN-1314761-C | Filler reinforced polyether imide resin composition and molded article thereof | GEN ELECTRIC (US) | 2007-05-09 | — | — | CN | disclosed |
| CN-1659234-A | filler-reinforced polyetherimide resin composition and molded article thereof | GEN ELECTRIC (US) | 2005-08-24 | — | — | CN | disclosed |
| US-20050131105-A1 | Filler reinforced polyether imide resin composition and molded article thereof | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2005-06-16 | — | — | US | disclosed |
| EP-1497374-A1 | FILLER REINFORCED POLYETHER IMIDE RESIN COMPOSITION AND MOLDED ARTICLE THEREOF | GENERAL ELECTRIC COMPANY (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003087226-A1 | FILLER REINFORCED POLYETHER IMIDE RESIN COMPOSITION AND MOLDED ARTICLE THEREOF | GENERAL ELECTRIC COMPAMY (US) | 2003-10-23 | — | — | WO | disclosed |