Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.65 |
| ▸ | MMP2 | P08253 | 5/20 | 0.65 |
| ▸ | MMP9 | P14780 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.46 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.46 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.46 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3029548 | 1.00 | MMP1 (0.65) | MMP1MMP2MMP9ALDH1A1ALOX12 | |
| Hydrochloric Acid SCHEMBL4626102 | 0.98 | MMP1 (0.63) | MMP1MMP2MMP9ALDH1A1ALOX12 | |
| SCHEMBL4626453 | 0.89 | PLA2G1B (0.55) | MMP1MMP2MMP9ALDH1A1ALOX12 | |
| SCHEMBL4625967 | 0.89 | PLA2G1B (0.55) | MMP1MMP2MMP9ALDH1A1POLB | |
| SCHEMBL7040017 | 0.89 | PLA2G1B (0.55) | MMP1MMP2MMP9ALDH1A1POLB | |
| SCHEMBL7044898 | 0.89 | PLA2G1B (0.55) | MMP1MMP2MMP9ALDH1A1ALOX12 | |
| SCHEMBL4624926 | 0.89 | MAPT (0.55) | MMP1MMP2MMP9ALDH1A1ALOX12 | |
| SCHEMBL4624830 | 0.89 | LMNA (0.59) | MMP1MMP2MMP9ALDH1A1ALOX12 | |
| SCHEMBL4626674 | 0.89 | MMP1 (0.53) | MMP1MMP2MMP9ALDH1A1POLB | |
| SCHEMBL4624960 | 0.89 | MMP1 (0.53) | MMP1MMP2MMP9ALDH1A1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1903028-A1 | Conjugates of glutamate and NMDA receptor channel blockers without excito-toxic effects | Tschollar,, Werner (CH) | 2008-03-26 | — | — | EP | claimed |
| EP-1296940-A1 | AMIDINE DERIVATIVES AS SELECTIVE ANTAGONISTS OF NMDA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2003-04-02 | — | — | EP | claimed |
| WO-2001098262-A1 | AMIDINE DERIVATIVES AS SELECTIVE ANTAGONISTS OF NMDA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-12-27 | — | — | WO | claimed |
| EP-1903028-A1 | Conjugates of glutamate and NMDA receptor channel blockers without excito-toxic effects | Tschollar,, Werner (CH) | 2008-03-26 | — | — | EP | disclosed |
| US-20060014801-A1 | Prevention and treatment of cognitive impairment using (R)-(-)-5-methyl-1-nicotynoyl-2-pyrazoline (MNP) and analogs | THE JOHNS HOPKINS UNIVERSITY (US) | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014801-A1 | Prevention and treatment of cognitive impairment using (R)-(-)-5-methyl-1-nicotynoyl-2-pyrazoline (MNP) and analogs | NNMT, NNT, SIRT5 | MMP1 1677/4885MMP2 2507/4885MMP9 1989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.