Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.59 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5213176 | 0.87 | TSHR (0.71) | TSHRSCN2ASCN10ACYP2C19CYP1A2 | |
| SCHEMBL31043805 | 0.84 | TSHR (0.53) | TSHRSCN2ASCN10ANPSR1NAMPT | |
| SCHEMBL5083050 | 0.84 | L3MBTL1 (0.69) | TSHRCYP2C19CYP1A2MEN1KMT2A | |
| SCHEMBL5077115 | 0.83 | HPGDS (0.67) | SCN2ASCN10AHPGDSMN1; SMN2RAB9A | |
| SCHEMBL4564344 | 0.83 | MAOB (0.58) | TSHRHPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5079678 | 0.83 | HDAC3 (0.58) | TSHRSCN2ASCN10ALMNAHDAC3 | |
| SCHEMBL8987867 | 0.83 | MEN1 (0.78) | TSHRCYP2C19CYP1A2CYP2C9NAMPT | |
| SCHEMBL5078937 | 0.83 | EPHX2 (0.60) | TSHRNAMPTSMN1; SMN2MAPK14HDAC1 | |
| SCHEMBL1569160 | 0.82 | CYP3A4 (0.74) | TSHRCYP2C19CYP1A2CYP2C9HPGD | |
| SCHEMBL31358834 | 0.80 | RAB9A (0.62) | CYP2C19CYP1A2CYP2C9HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080132505-A1 | Combination Of Cb2 Modulators And Pde4 Inhibitors For Use In Medicine | GLAXO GROUP LIMITED | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132505-A1 | Combination Of Cb2 Modulators And Pde4 Inhibitors For Use In Medicine | CNR2, CNR1, PDE4A | TSHR 1356/4885SCN2A 1766/4885SCN10A 2096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.