Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL9252451 | 0.98 | LMNA (0.45) | LMNAALDH1A1SMN1; SMN2TDP1KDM4E | |
| Methacrylic Acid SCHEMBL9252465 | 0.98 | LMNA (0.45) | LMNAALDH1A1SMN1; SMN2TDP1KDM4E | |
| Oxalic Acid SCHEMBL7319784 | 0.88 | SMN1; SMN2 (0.52) | LMNAALDH1A1SMN1; SMN2TDP1KDM4E | |
| Acetic Acid SCHEMBL443433 | 0.88 | SMN1; SMN2 (0.52) | LMNAALDH1A1SMN1; SMN2TDP1KDM4E | |
| Methacrylic Acid SCHEMBL11761808 | 0.86 | CYP2D6 (0.40) | LMNAALDH1A1SMN1; SMN2TDP1KDM4E | |
| Acetic Acid SCHEMBL10412876 | 0.86 | LMNA (0.50) | LMNAALDH1A1SMN1; SMN2TDP1KDM4E | |
| Bicarbonate SCHEMBL6755891 | 0.86 | SMN1; SMN2 (0.54) | LMNAALDH1A1SMN1; SMN2TDP1KDM4E | |
| Acetone SCHEMBL4283217 | 0.86 | GAA (0.54) | LMNAALDH1A1SMN1; SMN2TDP1KDM4E | |
| Hydrogen Peroxide SCHEMBL29268503 | 0.85 | SMN1; SMN2 (0.59) | LMNAALDH1A1SMN1; SMN2TDP1KDM4E | |
| Methacrylic Acid SCHEMBL1453919 | 0.84 | TSHR (0.67) | LMNAALDH1A1SMN1; SMN2TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107533175-A | Multilayer laminated film | 东丽株式会社 | 2018-01-02 | — | — | CN | disclosed |
| US-20080146831-A1 | Continuous Method for Producing Cyclohexyl(Meth)Acrylate | BASF AKTIENGESELLSCHAFT (DE) | 2008-06-19 | — | — | US | disclosed |