Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 12/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8654430 | 0.77 | FGF23 (0.46) | MAPK14PTGS2 | |
| SCHEMBL8389316 | 0.76 | MAPK14 (0.64) | MAPK14PTGS2PTGS1HTTNR3C2 | |
| SCHEMBL8266062 | 0.74 | MAPK14 (0.62) | MAPK14PTGS2PTGS1 | |
| SCHEMBL5694270 | 0.74 | MAPK14 (0.62) | MAPK14PTGS2PTGS1HTTNR3C2 | |
| SCHEMBL5550388 | 0.74 | MAPK14 (0.57) | MAPK14PTGS2PTGS1 | |
| SCHEMBL8652478 | 0.74 | PTGS2 (0.56) | PTGS2PTGS1 | |
| SCHEMBL8993560 | 0.71 | PTGS2 (0.34) | MAPK14PTGS2PTGS1 | |
| SCHEMBL8310544 | 0.71 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL7670704 | 0.70 | MAPK14 (0.47) | MAPK14PTGS2PTGS1HTTNR3C2 | |
| SCHEMBL21346789 | 0.69 | MAPK14 (0.52) | MAPK14PTGS2PTGS1HTTNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937264-A2 | COMBINATION THERAPY FOR THE TREATMENT OF URINARY FREQUENCY, URINARY URGENCY AND URINARY INCONTINENCE | Merck & Co., Inc. (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007146224-A2 | COMBINATION THERAPY FOR THE TREATMENT OF URINARY FREQUENCY, URINARY URGENCY AND URINARY INCONTINENCE | MERCK & CO., INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007044296-A2 | COMBINATION THERAPY FOR THE TREATMENT OF URINARY FREQUENCY, URINARY URGENCY AND URINARY INCONTINENCE | MERCK & CO., INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| EP-1761488-A1 | LACTAM TACHYKININ RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006002117-A1 | LACTAM TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2006-01-05 | — | — | WO | disclosed |
| EP-0724566-B1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 1998-10-07 | — | — | EP | disclosed |
| US-5663180-A | ANTIARTHRITIC, ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1997-09-02 | — | — | US | disclosed |
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| EP-0724566-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| US-5420287-A | 1,2 diarylcyclopentenyl compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1995-05-30 | — | — | US | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |
| WO-1995011883-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-05-04 | — | — | WO | disclosed |
| US-5344991-A | Sulfonyl or sulfamyl derivatives for treatment of arthritis and pain | G.D. SEARLE & CO. (US) | 1994-09-06 | — | — | US | disclosed |