Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.65 |
| ▸ | PRKCG | P05129 | 4/20 | 0.65 |
| ▸ | PRKCB | P05771 | 4/20 | 0.65 |
| ▸ | PRKCA | P17252 | 4/20 | 0.65 |
| ▸ | PRKCH | P24723 | 4/20 | 0.65 |
| ▸ | PRKCI | P41743 | 4/20 | 0.65 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.65 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.65 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.65 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.65 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.65 |
| ▸ | PRKACA | P17612 | 3/20 | 0.62 |
| ▸ | PRKACG | P22612 | 3/20 | 0.62 |
| ▸ | PRKACB | P22694 | 3/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4728844 | 0.93 | ROCK2 (0.62) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL4729640 | 0.93 | ROCK2 (0.74) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| Hydrochloric Acid SCHEMBL9194379 | 0.92 | ROCK2 (0.62) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL4727206 | 0.86 | ROCK2 (0.66) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL23951500 | 0.85 | PRKD3 (0.71) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL7326564 | 0.85 | ROCK2 (0.65) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL6795564 | 0.84 | MEN1 (0.60) | ROCK2ROCK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18477516 | 0.84 | CYP3A4 (0.67) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL7318375 | 0.82 | ROCK2 (0.71) | ROCK2ROCK1CYP3A4PRKD3PRKCG | |
| SCHEMBL17228334 | 0.82 | PRKD3 (0.65) | ROCK2ROCK1CYP3A4PRKD3PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080044390-A1 | Methods and compositions for the treatment of neurodegenerative disorders | CHDI, INCORPORATED | 2008-02-21 | — | — | US | disclosed |
| EP-0287696-B1 | ISOQUINOLINE DERIVATIVES | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1991-01-02 | — | — | EP | disclosed |
| US-4798897-A | (AMINOALKYL)AMINOSULFONYL-SUBSTITUTED CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1989-01-17 | — | — | US | disclosed |
| EP-0287696-A1 | Isoquinoline derivatives | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1988-10-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080044390-A1 | Methods and compositions for the treatment of neurodegenerative disorders | HTT, SNCA, NLN | ROCK2 2320/4885ROCK1 2248/4885CYP3A4 4801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.