Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Velnacrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.83 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.83 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.83 |
| ▸ | ACHE | P22303 | 1/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.83 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Velnacrine SCHEMBL637476 | 1.00 | TSHR (0.83) | TSHRCYP1A2CYP2C9ALDH1A1NR3C1 | |
| Velnacrine SCHEMBL7193446 | 1.00 | TSHR (0.83) | TSHRCYP1A2CYP2C9ALDH1A1NR3C1 | |
| Velnacrine SCHEMBL9634108 | 0.99 | TSHR (0.81) | TSHRCYP1A2CYP2C9ALDH1A1NR3C1 | |
| Velnacrine SCHEMBL14814443 | 0.96 | TSHR (0.77) | TSHRCYP1A2CYP2C9ALDH1A1NR3C1 | |
| Velnacrine SCHEMBL6129239 | 0.92 | TSHR (0.69) | TSHRCYP1A2CYP2C9ALDH1A1NR3C1 | |
| Velnacrine SCHEMBL194467 | 0.91 | CYP1A2 (1.00) | TSHRCYP1A2CYP2C9ALDH1A1NR3C1 | |
| Maleic Acid SCHEMBL9874286 | 0.85 | ACHE (0.60) | TSHRCYP1A2CYP2C9ALDH1A1NR3C1 | |
| Fumaric Acid SCHEMBL9874303 | 0.85 | ACHE (0.60) | TSHRCYP1A2CYP2C9ALDH1A1NR3C1 | |
| Maleic Acid SCHEMBL9875733 | 0.84 | ACHE (0.58) | TSHRCYP1A2CYP2C9ALDH1A1NR3C1 | |
| Fumaric Acid SCHEMBL9875742 | 0.84 | ACHE (0.58) | TSHRCYP1A2CYP2C9ALDH1A1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 811 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3807229-B1 | PROCESS FOR THE PRODUCTION OF COMPOSITE ARTICLES | NOURYON CHEMICALS INT BV (NL) | 2025-10-22 | — | — | EP | claimed |
| US-20250153150-A1 | HETEROGENEOUS CATALYST BASED ON MOLYBDENUM OXIDE AND ITS USE IN BIOMASS TRANSFORMATION PROCESSES | INSTITUTO MEXICANO DEL PETRÓLEO (MX) | 2025-05-15 | — | — | US | claimed |
| WO-2025068254-A1 | TREATMENT SYSTEM FOR TREATING WORKPIECES, AND METHOD FOR OPERATING SUCH A TREATMENT SYSTEM | EISENMANN GMBH (DE) | 2025-04-03 | — | — | WO | claimed |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | claimed |
| EP-4331094-A1 | METHOD FOR OPERATING AN ELECTROMAGNETIC POWER GENERATOR FOR A WHEEL, AND POWER GENERATOR FOR A WHEEL | Ronal AG (CH) | 2024-03-06 | — | — | EP | claimed |
| EP-4297868-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | Hoth Therapeutics, Inc. (US) | 2024-01-03 | — | — | EP | claimed |
| EP-3861039-B1 | HYDROGEL COMPOSITIONS | OPHTALMIC CIE (FR) | 2023-11-01 | — | — | EP | claimed |
| WO-2023175159-A1 | METHOD FOR OPERATING AN ELECTROMAGNETIC POWER GENERATOR FOR A WHEEL, AND POWER GENERATOR FOR A WHEEL | RONAL AG (CH) | 2023-09-21 | — | — | WO | claimed |
| WO-2022182658-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. (US) | 2022-09-01 | — | — | WO | claimed |
| EP-3934859-A1 | METHOD FOR DETERMINING A TRAJECTORY OF A ROBOT | Siemens Aktiengesellschaft (DE) | 2022-01-12 | — | — | EP | claimed |
| WO-1997048391-A2 | METHODS AND COMPOSITIONS COMPRISING R-IBUPROFEN | ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE (US) | 1997-12-24 | — | — | WO | claimed |
| WO-1994009787-A1 | SYNERGISTIC COMBINATION FOR THE THERAPY OF DEGENERATIVE AGEING DISEASES CONTAINING AN ADENOSINE ANTAGONIST AND A CHOLINOMIMETIC | BOEHRINGER INGELHEIM KG (DE) | 1994-05-11 | — | — | WO | claimed |
| EP-0563654-A1 | Risk determination for drug treatment | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-10-06 | — | — | EP | claimed |
| EP-0479999-A1 | DEVICE FOR THE NON-CONTACT MEASUREMENT OF SPEED, DISPLACEMENT DISTANCE AND/OR RANGE. | TABARELLI WERNER (LI) | 1992-04-15 | — | — | EP | claimed |
| EP-0465905-A1 | Ceiling cladding | Wilhelmi Werke GmbH & Co.KG (DE) | 1992-01-15 | — | — | EP | claimed |
| WO-1991016640-A1 | DEVICE FOR THE NON-CONTACT MEASUREMENT OF SPEED, DISPLACEMENT DISTANCE AND/OR RANGE | TABARELLI, WERNER (LI) | 1991-10-31 | — | — | WO | claimed |
| EP-0423483-A2 | Procedure for determining the state of charge of an accumulator | MERCEDES-BENZ AG (DE) | 1991-04-24 | — | — | EP | claimed |
| EP-0349811-A1 | Feed-back control system for a combustion engine | ROBERT BOSCH GMBH (DE) | 1990-01-10 | — | — | EP | claimed |
| EP-0237754-A1 | Method to control a fuel injection apparatus, and fuel injection apparatus | ROBERT BOSCH GMBH (DE) | 1987-09-23 | — | — | EP | claimed |
| WO-1986004417-A1 | METHOD AND DEVICE FOR THE DETERMINATION OF CHARACTERISTIC VALUES, PARTICULARLY OF GRAIN | OETIKER HANS (CH) | 1986-07-31 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250153150-A1 | HETEROGENEOUS CATALYST BASED ON MOLYBDENUM OXIDE AND ITS USE IN BIOMASS TRANSFORMATION PROCESSES | SQLE, FASN, SCD | TSHR 4156/4885CYP1A2 190/4885CYP2C9 174/4885 |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | TACR1, ACHE, TACR2 | TSHR 1743/4885CYP1A2 1513/4885CYP2C9 3070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.