Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 10/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949238 | 1.00 | HCAR2 (0.48) | HCAR2ALDH1A1TSHRTP53EGLN1 | |
| SCHEMBL4017018 | 1.00 | HCAR2 (0.48) | HCAR2ALDH1A1TSHRTP53EGLN1 | |
| Benzene SCHEMBL28352547 | 0.96 | HCAR2 (0.45) | HCAR2ALDH1A1TSHRTP53EGLN1 | |
| SCHEMBL8610770 | 0.91 | ALDH1A1 (0.48) | HCAR2ALDH1A1TSHRTDP1HSD17B10 | |
| SCHEMBL1428431 | 0.91 | ALDH1A1 (0.48) | HCAR2ALDH1A1TSHRTDP1HSD17B10 | |
| Maleic Acid SCHEMBL8429487 | 0.89 | ALDH1A1 (0.46) | HCAR2ALDH1A1TSHRTP53EGLN1 | |
| Acrylic Acid Methyl Ester SCHEMBL27979370 | 0.88 | HCAR2 (0.52) | HCAR2ALDH1A1TSHRTP53EGLN1 | |
| 2-Methoxyethanol SCHEMBL28669585 | 0.85 | HCAR2 (0.40) | HCAR2ALDH1A1TSHRTDP1KDM4E | |
| Alcohol SCHEMBL9000833 | 0.83 | ALDH1A1 (0.41) | HCAR2ALDH1A1TSHRTDP1HSD17B10 | |
| Styrene SCHEMBL28843157 | 0.82 | ALDH1A1 (0.41) | HCAR2ALDH1A1TSHRTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147081-A1 | OPTICAL FILM, PROTECTION FILM FOR POLARIZER FILM, POLARIZER PLATE FABRICATED THEREFROM, AND DISPLAY DEVICE EMPLOYING THEREOF | LG CHEM, LTD. (KR) | 2008-12-04 | — | — | WO | disclosed |