Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 7/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949238 | 0.89 | HCAR2 (0.48) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| SCHEMBL4017018 | 0.89 | HCAR2 (0.48) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Crotonic Acid SCHEMBL28085029 | 0.89 | ALDH1A1 (0.41) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL5086355 | 0.89 | HCAR2 (0.48) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Acrylic Acid SCHEMBL9810222 | 0.85 | LMNA (0.50) | ALDH1A1TSHRTP53TDP1HSD17B10 | |
| Benzene SCHEMBL28352547 | 0.85 | HCAR2 (0.45) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Acetic Acid SCHEMBL28803626 | 0.84 | ALDH1A1 (0.55) | ALDH1A1TSHRTDP1HSD17B10THRB | |
| Acetic Acid SCHEMBL2896489 | 0.84 | ALDH1A1 (0.55) | ALDH1A1TSHRTDP1HSD17B10THRB | |
| SCHEMBL15963 | 0.84 | ALDH1A1 (0.61) | ALDH1A1TSHRTDP1HSD17B10THRB | |
| SCHEMBL28170047 | 0.84 | ALDH1A1 (0.61) | ALDH1A1TSHRTDP1HSD17B10THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0546750-B1 | Coated recording sheets for electrostatic printing processes | XEROX CORP (US) | 1997-05-28 | — | — | EP | claimed |
| EP-3475958-A1 | ELECTRICALLY CONDUCTIVE SHAPED BODY WITH A POSITIVE TEMPERATURE COEFFICIENT | Thüringisches Institut für Textil- und Kunststoff-Forschung e.V. (DE) | 2019-05-01 | — | — | EP | disclosed |
| EP-0848750-B1 | PROCESS FOR PRODUCING GRANULATED PRECURSORS OF LOW ALKALINITY DETERGENTS | HENKEL KGAA (DE) | 1999-11-10 | — | — | EP | disclosed |