Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 5/20 | 0.33 |
| ▸ | FAAH | O00519 | 2/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | PDE5A | O76074 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5081008 | 0.85 | KDM4E (0.40) | CYP1A2CYP19A1CYP2C9CYP2C19HTR7 | |
| SCHEMBL5083213 | 0.83 | KCNN4 (0.42) | CYP1A2CYP2C19HTR7ADRB2L3MBTL1 | |
| SCHEMBL4723651 | 0.83 | CYP1A2 (0.48) | CYP1A2CYP19A1CYP2C9CYP2C19CNR2 | |
| SCHEMBL4721568 | 0.81 | PDE5A (0.41) | CYP1A2CYP19A1CYP2C9CYP2C19ADRB2 | |
| SCHEMBL4723561 | 0.81 | ALDH1A1 (0.40) | PDE5AKDM4EMAPTNPSR1TDP1 | |
| SCHEMBL5083181 | 0.78 | KDM4E (0.41) | CYP1A2CYP19A1CYP2C9CYP2C19HTR7 | |
| SCHEMBL5083191 | 0.78 | KDM4E (0.41) | CYP1A2CYP19A1CYP2C9CYP2C19HTR7 | |
| SCHEMBL5087247 | 0.74 | ADRA2A (0.30) | — | |
| SCHEMBL5083208 | 0.72 | KCNN4 (0.31) | KDM4E | |
| SCHEMBL5081002 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509250-B1 | METHODS COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR MODULATING BONE GROWTH | YISSUM RES DEV CO (IL) | 2008-05-07 | — | — | EP | claimed |