Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 10/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 9/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.43 |
| ▸ | PRKACA | P17612 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30995223 | 0.93 | ROCK1 (0.46) | OPRM1OPRD1OPRK1OPRL1RPS6KB1 | |
| SCHEMBL16103839 | 0.77 | OPRM1 (0.44) | OPRM1OPRD1OPRK1OPRL1CYP11B2 | |
| SCHEMBL30995117 | 0.76 | CYP11B2 (0.44) | CYP11B2CYP11B1 | |
| SCHEMBL30344944 | 0.74 | KMT2A (0.53) | OPRM1OPRD1OPRK1OPRL1CYP11B2 | |
| SCHEMBL30995183 | 0.74 | PRKACA (0.37) | RPS6KB1ROCK1PRKACAGSK3B | |
| SCHEMBL30995162 | 0.74 | CYP11B2 (0.44) | OPRM1OPRL1RPS6KB1ROCK1PRKACA | |
| SCHEMBL28330578 | 0.74 | PLA2G10 (0.47) | OPRM1OPRD1OPRK1OPRL1OGFRL1 | |
| SCHEMBL30995229 | 0.73 | ABL1 (0.37) | OPRM1CYP11B2CYP11B1 | |
| SCHEMBL12491808 | 0.73 | OPRM1 (0.41) | OPRM1OPRD1OPRK1OPRL1OGFRL1 | |
| SCHEMBL12490206 | 0.73 | OPRM1 (0.67) | OPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007756-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmceuticals Incorporated (US) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007117715-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-18 | — | — | WO | disclosed |