Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5091959 | 0.90 | PLA2G2A (0.45) | PLA2G2AMAPTSMN1; SMN2HPGDCYP3A4 | |
| SCHEMBL5093348 | 0.90 | PKM (0.44) | PLA2G2AKDM4EMAPTHTTSMN1; SMN2 | |
| SCHEMBL5097655 | 0.87 | MAPT (0.46) | PLA2G2AALDH1A1MAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL5097671 | 0.87 | RECQL (0.46) | PLA2G2AALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL5088547 | 0.86 | PLA2G2A (0.47) | PLA2G2AKDM4EMAPTSMN1; SMN2NPC1 | |
| SCHEMBL5090503 | 0.86 | PLA2G2A (0.51) | PLA2G2AALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL5090535 | 0.85 | DHODH (0.52) | PLA2G2AMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL5091911 | 0.83 | NPC1 (0.53) | PLA2G2AALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL5088571 | 0.81 | RAB9A (0.48) | PLA2G2AALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL5093345 | 0.81 | PLA2G2A (0.45) | PLA2G2AKDM4EHTTSMN1; SMN2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |