Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 4/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5090570 | 0.88 | KDM4E (0.44) | DHODHKDM4EGRM2DPP4PDE10A | |
| SCHEMBL4620316 | 0.86 | PLA2G2A (0.47) | PLA2G2ADHODHKDM4ECASP3HSD17B10 | |
| SCHEMBL5093348 | 0.86 | PKM (0.44) | PLA2G2ADHODHKDM4EPRNPSMN1; SMN2 | |
| SCHEMBL5090548 | 0.86 | PLA2G2A (0.43) | PLA2G2ADHODHKDM4ECASP3HSD17B10 | |
| SCHEMBL5088547 | 0.85 | PLA2G2A (0.47) | PLA2G2ADHODHKDM4EPRNPSMN1; SMN2 | |
| SCHEMBL5097655 | 0.84 | MAPT (0.46) | PLA2G2ASMN1; SMN2 | |
| SCHEMBL5098641 | 0.84 | PLA2G2A (0.43) | PLA2G2ADHODHKDM4ECASP3HSD17B10 | |
| SCHEMBL5097651 | 0.84 | PLA2G2A (0.53) | PLA2G2ADHODHKDM4EPRNPSMN1; SMN2 | |
| SCHEMBL4621671 | 0.83 | PLA2G2A (0.45) | PLA2G2ADHODHKDM4ECASP3HSD17B10 | |
| SCHEMBL5093369 | 0.83 | PLA2G2A (0.45) | PLA2G2ADHODHKDM4ECASP3HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |